Synthesis and cytoprotective antiulcer activity of 2- or 4-(1H-pyrazol- 1-yl)pyrimidine derivatives related to mepirizole and dulcerozine

DOI: 10.1248/cpb.44.1700

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Chemical and Pharmaceutical Bulletin p. 1700 - 1706 (1996)

Update date:2022-08-10

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Authors:

Ikeda, Masazumi

Maruyama, Kazumi

Nobuhara, Youichi

Yamada, Toshihiro

Okabe, Susumu

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Article abstract of DOI:10.1248/cpb.44.1700

(1H-Pyrazol-1-yl)-, (1H-imidazol-1-yl)-, and (1H-1,2,4-triazol-1- yl)pyrimidines were prepared and evaluated for cytoprotective antiulcer activity. Among them, 4-methoxy-6-methyl-2-(1H-pyrazol-1-yl)pyrimidine (18) showed potent inhibition of the HCl-ethanol-induced and water-immersion stress-induced ulcers in rats, as well as low acute toxicity.

Full text of DOI:10.1248/cpb.44.1700

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