Welcome to LookChem.com Sign In|Join Free

CAS

  • or
BOC-L-2-Chlorophe, also known as a BOC-protected derivative of L-2-chlorophenylalanine, is an amino acid with potential antineoplastic activity. It is widely used in research and pharmaceutical applications due to its ability to study the effects of L-2-chlorophenylalanine on various biological processes, such as protein synthesis and neurotransmitter release. With its versatility, BOC-L-2-Chlorophe plays a crucial role in scientific and medical research.

114873-02-8 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 114873-02-8 Structure
  • Basic information

    1. Product Name: BOC-L-2-Chlorophe
    2. Synonyms: (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID;tert-Butoxycarbonyl-L-2-chlorophenylalanine;RARECHEM BK PT 0002;N-ALPHA-T-BUTOXYCARBONYL-2-CHLORO-L-PHENYLALANINE;N-ALPHA-T-BUTOXYCARBONYL-O-CHLORO-L-PHENYLALANINE;N-ALPHA-TERT-BUTYLOXYCARBONYL-2-CHLORO-L-PHENYLALANINE;BOC-L-2-CHLOROPHE;BOC-L-2-CHLOROPHENYLALANINE
    3. CAS NO:114873-02-8
    4. Molecular Formula: C14H18ClNO4
    5. Molecular Weight: 299.75
    6. EINECS: N/A
    7. Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids;Peptide;a-amino
    8. Mol File: 114873-02-8.mol
  • Chemical Properties

    1. Melting Point: 94-100 °C
    2. Boiling Point: 452.5 °C at 760 mmHg
    3. Flash Point: 227.5 °C
    4. Appearance: /
    5. Density: 1.245 g/cm3
    6. Vapor Pressure: 5.61E-09mmHg at 25°C
    7. Refractive Index: 1.538
    8. Storage Temp.: Store at 0°C
    9. Solubility: N/A
    10. PKA: 3.83±0.11(Predicted)
    11. BRN: 8778440
    12. CAS DataBase Reference: BOC-L-2-Chlorophe(CAS DataBase Reference)
    13. NIST Chemistry Reference: BOC-L-2-Chlorophe(114873-02-8)
    14. EPA Substance Registry System: BOC-L-2-Chlorophe(114873-02-8)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 114873-02-8(Hazardous Substances Data)

114873-02-8 Usage

Uses

Used in Research Applications:
BOC-L-2-Chlorophe is used as a research compound for studying the effects of L-2-chlorophenylalanine on biological processes. Its BOC protection allows for controlled release of the active amino acid, enabling researchers to investigate its impact on protein synthesis and neurotransmitter release.
Used in Pharmaceutical Applications:
BOC-L-2-Chlorophe is used as a building block in the synthesis of peptide-based drugs. Its antineoplastic properties make it a promising candidate for the development of new therapeutic agents targeting various types of cancer.
Used in Drug Development:
BOC-L-2-Chlorophe is used as a starting material for the creation of new chemical entities with potential therapeutic applications. Its unique structure and properties allow for the design and synthesis of novel compounds with improved pharmacological profiles and therapeutic benefits.

Check Digit Verification of cas no

The CAS Registry Mumber 114873-02-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,8,7 and 3 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 114873-02:
(8*1)+(7*1)+(6*4)+(5*8)+(4*7)+(3*3)+(2*0)+(1*2)=118
118 % 10 = 8
So 114873-02-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H18ClNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-6-4-5-7-10(9)15/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m1/s1

114873-02-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Aldrich

  • (15021)  Boc-Phe(2-Cl)-OH  ≥98.0% (TLC)

  • 114873-02-8

  • 15021-1G

  • 1,174.68CNY

  • Detail

114873-02-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-3-(2-chlorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

1.2 Other means of identification

Product number -
Other names Boc-Phe(2-Cl)-OH

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:114873-02-8 SDS

114873-02-8Relevant articles and documents

2H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design

Giroud, Maude,Kuhn, Bernd,Saint-Auret, Sarah,Kuratli, Christoph,Martin, Rainer E.,Schuler, Franz,Diederich, Fran?ois,Kaiser, Marcel,Brun, Reto,Schirmeister, Tanja,Haap, Wolfgang

, p. 3370 - 3388 (2018/05/01)

Macrocyclic inhibitors of rhodesain (RD), a parasitic cysteine protease and drug target for the treatment of human African trypanosomiasis, have shown low metabolic stability at the macrocyclic ether bridge. A series of acyclic dipeptidyl nitriles was developed using structure-based design (PDB ID: 6EX8). The selectivity against the closely related cysteine protease human cathepsin L (hCatL) was substantially improved, up to 507-fold. In the S2 pocket, 3,4-dichlorophenylalanine residues provided high trypanocidal activities. In the S3 pocket, aromatic residues provided enhanced selectivity against hCatL. RD inhibition (Ki values) and in vitro cell-growth of Trypanosoma brucei rhodesiense (IC50 values) were measured in the nanomolar range. Triazole-based ligands, obtained by a safe, gram-scale flow production of ethyl 1H-1,2,3-triazole-4-carboxylate, showed excellent metabolic stability in human liver microsomes and in vivo half-lives of up to 1.53 h in mice. When orally administered to infected mice, parasitaemia was reduced but without complete removal of the parasites.

Discovery of pyrrolopyrimidine inhibitors of Akt

Blake, James F.,Kallan, Nicholas C.,Xiao, Dengming,Xu, Rui,Bencsik, Josef R.,Skelton, Nicholas J.,Spencer, Keith L.,Mitchell, Ian S.,Woessner, Richard D.,Gloor, Susan L.,Risom, Tyler,Gross, Stefan D.,Martinson, Matthew,Morales, Tony H.,Vigers, Guy P.A.,Brandhuber, Barbara J.

scheme or table, p. 5607 - 5612 (2010/11/17)

The discovery and optimization of a series of pyrrolopyrimidine based protein kinase B (Pkb/Akt) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent inhibition of all three Akt isoforms and knockdown of phospho-PRAS40 levels in LNCaP cells and tumor xenografts.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 114873-02-8