457654-72-7

Upstream product

• 1254365-74-6 C₁₅H₂₀ClNO₄ 
• 114873-02-8 (R)-2-((tert-butoxycarbonyl)amino)-3-(2-chlorophenyl)propanoic acid 
• 67-56-1 methanol 
• 80126-50-7 (R)-2'-chlorophenylalanine 

Downstream Products

• 1610691-89-8 (R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-2-chlorophenylalanine methyl ester 
• 1610691-84-3 (R)-N-(2-chloroacetyl)-2-chlorophenylalanine methyl ester 

Relevant academic research and scientific papers

Rhodium-Catalyzed Enantioselective Synthesis of Oxazinones via an Asymmetric Ring Opening-Lactonization Cascade of Oxabicyclic Alkenes

The rhodium-catalyzed asymmetric ring opening reaction of oxabicyclic alkenes is shown to be an efficient method for synthesizing chiral heterocycles. We demonstrate that the pairwise combination of chiral catalyst with chiral amino-acid-derived pronucleophiles results in a stereodivergent synthesis of diastereomeric hydroxyesters. A favorable conformational preference induces the subsequent lactonization of one diastereomer leading to the highly enantioselective synthesis of oxazinones.

A diastereoselective construction of pyrazinoisoquinoline skeletons via tandem cyclization of phenylalanine derivatives: A facile synthesis of optically active pyrazinoisoquinolines

A facile and stereocontrolled construction of optically active pyrazinoisoquinoline skeletons based on tandem cyclization of enantiopure phenylalanine derivatives was examined. The reaction provided optically active 6,11b-trans pyrazinoisoquinoline ring systems in excellent diastereoselectivity, and this method was applicable to the cyclization of phenylalanine derivatives with diverse substituents.