114880-33-0Relevant articles and documents
Sandwich immunoassay as a high-throughput screening method for cross-coupling reactions
Vicennati, Paola,Bensel, Nicolas,Wagner, Alain,Creminon, Christophe,Taran, Frederic
, p. 6863 - 6866 (2005)
Catalyst sandwich: An efficient and sensitive high-throughput-screening method that uses sandwich immunoassays was developed and applied to the Sonogashira reaction. This new method is amenable to coupling reactions and allows the screening of more than 1
Intercepting the Banert cascade with nucleophilic fluorine: Direct access to α-fluorinated: N H-1,2,3-triazoles
Alexander,Kevorkian,Topczewski
supporting information, p. 5024 - 5027 (2021/05/28)
The treatment of propargylic azides with silver(i) fluoride in acetonitrile was found to yield α-fluorinated NH-1,2,3-triazoles via the Banert cascade. The reaction was regioselective and the products result from an initial [3,3] rearrangement. The reacti
An efficient nanocluster catalyst for Sonogashira reaction
Chen, Cheng,Chen, Li,Li, Man-Bo,Luo, Gen,Lv, Qi-Long,Wu, Zhikun,Xu, Guo-Yong,Yang, Jinlong,Yang, Ying,Ye, Sun-Feng,Yuan, Jinyun
, p. 206 - 213 (2021/08/16)
Pd together with CuI has been well known as the catalyst towards Sonogashira reaction, which provides an effective route to functional alkynes. However, the achievement of high activity and selectivity of this catalytic system is still challenging in some cases. Illustrative examples include their low activity for aryl chloride substrates, and switched selectivity to oxidative coupling products in air atmosphere. In this work, a Cu-incorporated Au13 nanocluster [Au13Cu2(PPh3)6(SC2H4Ph)6]+[NO3]- (Au13Cu2) was designed and prepared in high yield via rapid synthesis. This atomically precise nanocluster shows the potential to be a novel catalytic system for Sonogashira reaction, featuring high activity and selectivity, as well as good recyclability even in air atmosphere.
Transition-Metal-Free Synthesis of Electron Rich 1,3-Dienes via Base Promoted Isomerization of Propargylic Ethers
Liu, Chunxiang,Deng, Guogang,Li, Xin,Xu, Yiren,Yu, Kaili,Chen, Wen,Zhang, Hongbin,Yang, Xiaodong
supporting information, p. 483 - 487 (2020/01/25)
Herein, a novel and scalable synthesis of electron rich 1,3-dienes based on KOtBu mediated isomerization of propargylic ether derivatives was developed. This new process features easy handling reaction conditions, transition-metal-free isomerization, high isolated yields, and most of all, it could be used for modification of natural products at late stage functionalizations.
Pyrazine- and pyridine-substituted prop-2-yn-1-ols, but-3-yn-2-ols, and but-3-yn-2-ones –purification, stability, and handling revised
Schindler, Claudia,Schulzke, Carola
, p. 1008 - 1013 (2016/08/26)
A short series of alkynyl-substituted pyrazine and pyridine derivatives was synthesized by the palladium-catalyzed Sonogashira cross-coupling reactions between aryl halides and alkynes. All the products are either white solids or colorless liquids, which is partly in contrast to previous reports. After purification, a color change or intense darkening was observed, in some cases starting almost immediately. Both, the nature of the heteroaromatic ring and the substituents of the alkyne moiety affect their stability. Herein details of synthesis, characterization, and, most importantly, purification and handling are reported.
Polypyrrole-supported graphite felt for acetylene coupling reaction in solid phase
Kashiwagi, Yoshitomo,Chiba, Shinya,Ikezoe, Hiroshi,Anzai, Jun-Ichi
, p. 2513 - 2516 (2007/10/03)
Substrate immobilization on graphite felt for solid-phase acetylene coupling reaction was achieved by electrochemical polymerization of the substrate precursor containing a pyrrole side chain, where the amount of substrate on the electrode surface was easily controlled by the number of repeated cyclic voltammetric scannings. Couplings between terminal acetylenes and the iodobenzene-modified graphite felt electrode or aromatic iodides and the terminal acetylene-modified graphite felt electrode in the presence of palladium catalyst proceeded smoothly in satisfactory yields.
Lactol PAF antagonists
-
, (2008/06/13)
The invention encompasses compounds of general formula I: STR1 wherein W represents an imidazo[4,5-c]pyridyl group, optionally substituted with one or more substituents selected from C1 -C6 alkyl, C1 -C6 alkoxy, halo, CF, and CN; and Z, R1, R2, R3, R4, R5, R6 are variables. These compounds are useful as antagonists of platelet activating factor.
