115147-72-3 Usage
Uses
Used in Molecular Biology and Biochemistry:
DC-ME PHOSPHONAMIDITE is used as a phosphoramidite building block for the solid-phase synthesis of DNA and RNA. It is essential for the formation of phosphodiester bonds between nucleoside units, allowing for the creation of synthetic nucleic acids.
Used in Research and Diagnostic Applications:
DC-ME PHOSPHONAMIDITE is used as a key reagent in research and diagnostic applications, enabling the efficient and reliable synthesis of oligonucleotides and nucleic acids. This facilitates the study of genetic information, disease mechanisms, and the development of diagnostic tools.
Check Digit Verification of cas no
The CAS Registry Mumber 115147-72-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,1,4 and 7 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 115147-72:
(8*1)+(7*1)+(6*5)+(5*1)+(4*4)+(3*7)+(2*7)+(1*2)=103
103 % 10 = 3
So 115147-72-3 is a valid CAS Registry Number.
115147-72-3Relevant articles and documents
Synthesis of Alkylphosphon(othio)ate Analogues of DNA
Roelen, H. C. P. F.,Elst, H. van den,Dreef, C. E.,Marel, G. A. van der,Boom, J. H. van
, p. 2357 - 2360 (2007/10/02)
Easily accessible bis(diisopropylamino)alkylphosphines (alkyl is methyl, n-butyl or n-octyl) are convenient reagents for the synthesis of DNA fragments having an alkylphosphonate or alkylphosphonothioate linkage at a predetermined site in solution and on
OLIGODEOXYNUCLEOSIDE METHYLPHOSPHONATES: SYNTHESIS AND ENZYMIC DEGRADATION
Agrawal, Sudhir,Goodchild, John
, p. 3539 - 3542 (2007/10/02)
The automated synthesis of oligodeoxynucleosides containing methylphosphonate linkages has been improved by using nucleoside methylphosphonamidites as starting materials.It was found that two adjacent methylphosphonate linkages protect an oligomer from degradation by snake venom phosphodiesterase or spleen phosphodiesterase.
