115201-28-0

Basic information

• Product Name: HCl-Val-Pyrrolidide
• Synonyms: HCl-Val-Pyrrolidide;(2S)-2-Amino-3-methyl-1-pyrrolidin-1-ylbutan-1-one hydrochloride;(2S)-2-amino-3-methyl-1-pyrrolidin-1-ylbutan-1-one
• CAS NO: 115201-28-0
• Molecular Formula: C₉H₁₈N₂O*ClH
• Molecular Weight: 206.71296
• EINECS: -0
• Mol File: 115201-28-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: HCl-Val-Pyrrolidide(CAS DataBase Reference)
• NIST Chemistry Reference: HCl-Val-Pyrrolidide(115201-28-0)
• EPA Substance Registry System: HCl-Val-Pyrrolidide(115201-28-0)

Safety Data

• Hazardous Substances Data: 115201-28-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
HCl-Val-Pyrrolidide is used as a building block for the synthesis of pharmaceuticals, bioconjugates, and other bioactive molecules. Its chemical structure allows for the formation of peptide bonds and modification of peptide structures, making it a valuable component in the development of new compounds with therapeutic potential.
Used in Peptide Chemistry:
In peptide chemistry, HCl-Val-Pyrrolidide is used as a key component for the synthesis of peptides. Its ability to form peptide bonds and modify peptide structures enables the creation of novel peptides with specific functions and properties.
Used in Drug Development:
HCl-Val-Pyrrolidide is used as a starting material for the development of new drugs. Its versatility in forming peptide bonds and modifying peptide structures allows for the design of innovative therapeutic agents with improved efficacy and selectivity.
Used in Biotechnology:
In the field of biotechnology, HCl-Val-Pyrrolidide is utilized for the synthesis of bioconjugates and other bioactive molecules. Its chemical properties make it an essential component in the development of new biotechnological applications, such as targeted drug delivery systems and diagnostic tools.

Upstream product

• 130013-62-6 (S)-tert-butyl 3-methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-ylcarbamate 

Downstream Products

• 136328-76-2 2-(3,4-dichlorophenyl)-N-propyl-N-<(1S)-1-(1-methylethyl)-2-(1-pyrrolidinyl)ethyl>acetamide 
• 115200-75-4 2-(3,4-dichlorophenyl)-N-ethyl-N-<(1S)-1-(1-methylethyl)-2-(1-pyrrolidinyl)ethyl>acetamide 
• 115200-92-5 2-(3,4-dichlorophenyl)-N-<(1S)-1-(1-methylethyl)-2-(1-pyrrolidinyl)ethyl>acetamide 
• 115201-27-9 2-(3,4-Dichloro-phenyl)-N-[(S)-2-methyl-1-(pyrrolidine-1-carbonyl)-propyl]-acetamide 

Relevant articles and documents

Catalytic enantioselective synthesis of sterically demanding alcohols using di(2°-alkyl)zinc prepared by the refined Charette's method

A highly practical, catalytic enantioselective 2°-alkyl addition to aldehydes and ketones was developed. Chiral phosphoramide ligand (1) with salt-free and solvent-free di(2°-alkyl)zinc reagents prepared from (2°-alkyl)MgCl was essential. The Royal Society of Chemistry 2010.

Structure/Activity Studies Related to 2-(3,4-Dichlorophenyl)-N-methyl-N-acetamides: A Novel Series of Potent and Selective κ-Opioid Agonists

This paper describes the synthesis of a series of N-acetamides 1, variously substituted at the carbon adjacent to the amide nitrogen (C1), and related analogues, together with their biological evaluation as opioid κ agonists.In the first part of the study, the variants in N-acyl, N-alkyl, and amino functions were explored when the substituent at C1 was 1-methylethyl and the optimum was found to be exemplified by 2-(3,4-dichlorophenyl)-N-methyl-N-acetamide (13).Subsequently, racemic or chiral amino acids were used to introduce other alkyl and aryl substituents at C1 of the ethyl linking moiety.A series of potent compounds, bearing substituted-aryl groups at C1, were discovered, typified by 2-(3,4-dichlorophenyl)-N-methyl-N-acetamide (48), which was 5-fold more active as the racemate than 13 in vitro and exhibited potent naloxone-reversible analgesic effects (ED50 = 0.04 mg/kg sc) in a mouse abdominal constriction model.