115220-57-0Relevant articles and documents
Carbon-carbon bond construction on solid support: Triethylborane-induced radical reactions of oxime ethers
Miyabe, Hideto,Nishimura, Azusa,Fujishima, Yumi,Naito, Takeaki
, p. 1901 - 1907 (2003)
The triethylborane-induced solid-phase radical reaction was studied. The solid-phase radical reaction of oxime ether anchored to Wang resin proceeded smoothly to give the α-amino acid derivatives. The carbon-carbon bond-forming radical reaction of TentaGe
α-N-HYDROXYAMINO ACID DERIVATIVES
Kolasa, Teodozyj,Sharma, Sushil K.,Miller, Marvin J.
, p. 5431 - 5440 (2007/10/02)
Reactions of organolithium reagents with glyoxylate derived oximes provided a direct route to α-N-hydroxyamino acids.The process required direct attachment of an ionizable group to the glyoxylate carbonyl to prevent competitive reactions.The procedure allowed for direct formation of the α-chiral center of the newly formed α-N-hydroxyamino acid derivative.Introduction of potential chiral auxiliaries on the oxime oxygen resulted in modest diastereoselection.In most instances, use of chiral glyoxylamides also gave low diastereoselectivity.
REACTION OF ORGANOMETALLICS WITH OXIMES. SYNTHESIS OF α-N-HYDROXY AMINO ACIDS
Kolasa, Teodozyj,Sharma, Sushil,Miller, Marvin J.
, p. 4973 - 4976 (2007/10/02)
Reaction of organolithium reagents with glyoxylate and pyruvate derived oximes provides a direct ruote for the synthesis of unusual α-N-hydroxy amino acids.
