77845-97-7Relevant articles and documents
Ruthenium-Catalyzed Asymmetric Allylic Alkylation of Isatins
Kalnmals, Christopher A.,Parkin, Sean,Ramakrishnan, Divya,Ryan, Michael C.,Smaha, Rebecca W.,Trost, Barry M.
supporting information, (2020/04/02)
A new ruthenium-based catalytic system for branched-selective asymmetric allylic alkylation is disclosed and applied to the synthesis of chiral isatin derivatives. The catalyst, which is generated in situ from commercially available CpRu(MeCN)3PF6 and a BINOL-derived phosphoramidite, is both highly active (TON up to 180) and insensitive to air and moisture. Additionally, the N-alkylated isatins accessible using this methodology are versatile building blocks that are readily transformed into chiral analogs of achiral drug molecules.
COMPOUNDS FOR TREATMENT OF GLIOBLASTOMA
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Paragraph 00258; 00352-00353, (2018/09/08)
The present invention relates to compounds and methods for the treatment of glioblastoma, as well as to a pharmaceutical composition comprising said compounds. More specifically the invention relates to substituted quinoline derivatives having the formula (I), (II) or (III), and a pharmaceutical composition comprising said compounds for the treatment of cancer. (Formulae (I), (II), (III))
On the scope of diastereoselective allylation of various chiral glyoxylic oxime ethers with allyltributylstannane in the presence of?a Lewis acid and triallylaluminum
Kulkarni, Neelesh A.,Yao, Ching-Fa,Chen, Kwunmin
, p. 7816 - 7822 (2008/02/07)
The nucleophilic allylation of various chiral auxiliaries derived glyoxylic oxime ethers was studied. The use of allyltributylstannane in the presence of a Lewis acid and triallylaluminum provided the corresponding homoallylic amines in high chemical yiel
