115299-16-6

Basic information

• Product Name: 2-(2-METHOXY-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2-(2-METHOXY-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;ethyl 2-(2-methoxyphenyl)thiazole-4-carboxylate;4-Thiazolecarboxylic acid, 2-(2-methoxyphenyl)-, ethyl ester;ethyl 2-(2-Methoxyphenyl)thiazol-4-carboxylate;2-(2-Methoxyphenyl)-,4-thiazolecarboxylic acid ethyl ester
• CAS NO: 115299-16-6
• Molecular Formula: C₁₃H₁₃NO₃S
• Molecular Weight: 263.31
• Mol File: 115299-16-6.mol

Chemical Properties

• Boiling Point: 408.49°C at 760 mmHg
• Flash Point: 200.848°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(2-METHOXY-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-METHOXY-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(115299-16-6)
• EPA Substance Registry System: 2-(2-METHOXY-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(115299-16-6)

Safety Data

• Hazardous Substances Data: 115299-16-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-Methoxy-phenyl)-thiazole-4-carboxylic acid ethyl ester is used as an intermediate in the synthesis of pharmaceuticals for its potential biological activities, such as anti-inflammatory, anti-cancer, and antimicrobial properties. It aids in the development of new drugs for the treatment of various diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 2-(2-Methoxy-phenyl)-thiazole-4-carboxylic acid ethyl ester is used as a building block for the preparation of agrochemicals with potential pesticidal and herbicidal properties. Its synthesis contributes to the development of effective and environmentally friendly solutions for crop protection.
Used in Organic Synthesis:
2-(2-Methoxy-phenyl)-thiazole-4-carboxylic acid ethyl ester is used as a versatile building block in organic synthesis. Its ester form allows for further functionalization and modification, enabling the preparation of a wide range of chemical compounds with diverse applications in various industries.
Used in Research and Development:
2-(2-METHOXY-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER is also utilized in research and development for exploring its potential applications in various fields, such as drug discovery, material science, and chemical engineering. Its unique structure and properties make it a valuable tool for understanding and developing new chemical processes and products.

InChI:InChI=1/C13H13NO3S/c1-3-17-13(15)10-8-18-12(14-10)9-6-4-5-7-11(9)16-2/h4-8H,3H2,1-2H3

Upstream product

• 14214-10-9 ethyl diazopyruvate 
• 42590-97-6 2-methoxythiobenzamide 
• 868-59-7 L-cysteine ethyl ester hydrochloride 
• 135-02-4 ortho-anisaldehyde 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 885279-11-8 2-(2-methoxyphenyl)thiazole-4-carbaldehyde 
• 187793-07-3 2-(2'-methoxyphenyl)-4-hydroxymethylthiazole 

Relevant articles and documents

I2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles

The efficient synthesis of 2-substituted thiazoles and benzothiazoles has been accomplished employing readily available cysteine esters and 2-aminobenzenethiols as N and S sources. The reaction proceeds under an I2/TBHP system and involves a on

New Aryl-1,3-thiazole-4-carbohydrazides, Their 1,3,4-Oxadiazole-2-thione, 1,2,4-Triazole, Isatin-3-ylidene and Carboxamide Derivatives. Synthesis and Anti-HIV Activity

A series of isatin-3-ylidene (6a-i) and arylthiazolyl-1,3,4-oxadiazole-2- thione derivatives 7a-i derived from arylthiazolyl carbohydrazide analogs 4a-i were synthesized. Analogously, coupling of 4f with various amino acid methyl esters in the presence of HOBt/DCC reagents afforded the carboxamide derivatives 9a-d. The newly synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. All compounds are inactive, except compounds 9b and 9c which showed inhibition of HIV-1 with EC50 = 2:34 μgmL-1, and 1.12 μgmL-1 with therapeutic indexes (SI) of 9 and 1, respectively.

PROTEASE INHIBITORS

Disclosed herein is a compound of the formula STR1 known as 2-[N-(N-benzyloxycarbonyl-L-leucinyl)]-2'-[N'-[4-(N,N-dimethylaminomethyl) benzyloxy]carbonyl-L-leucinyl]carbohydrazide; and pharmaceutically acceptable salts, hydrates and solvates thereof.

Synthesis of 2-substituted-4-carbethoxythiazoles

In the presence of boron trifluoride etherate, aryl and alkylthioamides react with ethyl diazopyruvate to give high yields of corresponding thiazoles.