115314-17-5

Basic information

• Product Name: (R)-(-)-Glycidyl nosylate
• Synonyms: (R)-GLYCIDYL 3-NITROBENZENESULFONATE;(R)-(-)-GLYCIDYL-3-NOSYLATE;(R)-2,3-EPOXY-1-PROPYL-3-NITROBENZENESULFONATE;BENZENESULFONIC ACID, 3-NITRO-, (2R)-OXIRANYLMETHYL ESTER;3-NITROBENZENESULFONIC ACID (R)-GLYCIDYL ESTER;(2R)-(-)-GLYCIDYL-3-NITROBENZENESULFONATE;(2R)-(-)-Glycidyl-3-nitrobenzenesulphonate;(2R)-(-)-GLYCIDYL 3-NITROBENZENE-
• CAS NO: 115314-17-5
• Molecular Formula: C₉H₉NO₆S
• Molecular Weight: 259.24
• EINECS: 1308068-626-2
• Product Categories: chiral;CHIRAL COMPOUNDS;Chiral Reagents;Heterocycles;Sulfur & Selenium Compounds
• Mol File: 115314-17-5.mol

Chemical Properties

• Melting Point: 59-63 °C
• Boiling Point: 432.2 ºC at 760 mmHg
• Flash Point: 215.2 ºC
• Appearance: Slightly yellow/Crystalline Needles or Powder
• Density: 1.5881 (rough estimate)
• Refractive Index: 1.5270 (estimate)
• Storage Temp.: -20°C
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• CAS DataBase Reference: (R)-(-)-Glycidyl nosylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-Glycidyl nosylate(115314-17-5)
• EPA Substance Registry System: (R)-(-)-Glycidyl nosylate(115314-17-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36
• RIDADR: UN 1325 4.1/PG II
• RTECS: DB7192000
• HazardClass: 4.1
• PackingGroup: II
• Hazardous Substances Data: 115314-17-5(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(R)-(-)-Glycidyl nosylate is used as a key intermediate in the synthesis of various organic compounds. Its application in this field is due to its ability to undergo a range of chemical reactions, such as nucleophilic substitution, addition, and elimination, which allows for the creation of diverse molecular structures with potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (R)-(-)-Glycidyl nosylate is used as a starting material for the development of new drugs. Its unique chemical properties enable the synthesis of complex molecules with potential therapeutic effects, contributing to the discovery and innovation of novel pharmaceutical agents.
Used in Chemical Research:
(R)-(-)-Glycidyl nosylate is also utilized in chemical research as a model compound for studying various reaction mechanisms and exploring new synthetic pathways. Its reactivity and structural features make it an ideal candidate for understanding the fundamental principles of organic chemistry and advancing the field.
Used in Material Science:
In the field of material science, (R)-(-)-Glycidyl nosylate is employed in the development of new materials with specific properties. Its incorporation into polymers, for instance, can lead to the creation of materials with enhanced mechanical, thermal, or electrical properties, depending on the desired application.

InChI:InChI=1/C9H9NO6S/c11-10(12)7-2-1-3-9(4-7)17(13,14)16-6-8-5-15-8/h1-4,8H,5-6H2/t8-/m1/s1

Upstream product

• 121-51-7 3-nitrobenzenesulphonyl chloride 
• 60456-23-7 (S)-oxiranemethanol 
• 57044-25-4 (R)-oxiranemethanol 
• 60827-45-4 (S)-3-chloropropan-1,2-diol 
• 152333-94-3 glycidyl nosylate 

Downstream Products

• 119879-88-8 1-O-petroselinyl-sn-glycerol 3-O-m-nitrobenzenesulfonate 
• 157999-16-1 3,3'-Di-O-eicosamethylenedi-sn-glycerol 1,1'-bis(3'-nitrobenzenesulfonate) 
• 127705-30-0 3-Nitro-benzenesulfonic acid (R)-2-hydroxy-6-(tetrahydro-pyran-2-yloxy)-hex-4-ynyl ester 
• 132059-11-1 R-<1-(2-amino-3-nitrophenoxy)>-2',3'-epoxypropane 
• 132059-13-3 S-<1-(2-amino-3-nitrophenoxy)>-2',3'-epoxypropane 
• 125411-48-5 (S)-(-)-1--4-(oxiranylmethyl)piperazine 
• 165657-99-8 (R)-1-(diphenylmethyl)-4-(2,3-epoxypropyl)piperazine 
• 128994-25-2 (S)-(+)-1-(2-chlorophenoxy)-2,3-epoxypropane 
• 128994-26-3 (R)-(-)-1-(2-chlorophenoxy)-2,3-epoxypropane 
• 154968-42-0 (R)-4-(oxiran-2-ylmethoxy)benzaldehyde 
• 499789-59-2 methyl 2-(3-(R)oxiranylmethoxybenzyl)-tetrahydro-2-furancarboxylate 
• 330651-27-9 (R)-3-(3-(epoxymethoxy)phenyl)thieno[2,3-d]isoxazole 
• 66966-19-6 (R)-1-(2'-allyloxyphenoxy)-2,3-epoxypropane 
• 6452-71-7 1-[2-(allyloxy)phenoxy]-3-(isopropylamino)propan-2-ol 

Relevant articles and documents

Novel chiral stationary phases based on 3,5-dimethyl phenylcarbamoylated β-cyclodextrin combining cinchona alkaloid moiety

Novel chiral selectors based on 3,5-dimethyl phenylcarbamoylated β-cyclodextrin connecting quinine (QN) or quinidine (QD) moiety were synthesized and immobilized on silica gel. Their chromatographic performances were investigated by comparing to the 3,5-dimethyl phenylcarbamoylated β-cyclodextrin (β-CD) chiral stationary phase (CSP) and 9-O-(tert-butylcarbamoyl)-QN-based CSP (QN-AX). Fmoc-protected amino acids, chiral drug cloprostenol (which has been successfully employed in veterinary medicine), and neutral chiral analytes were evaluated on CSPs, and the results showed that the novel CSPs characterized as both enantioseparation capabilities of CD-based CSP and QN/QD-based CSPs have broader application range than β-CD-based CSP or QN/QD-based CSPs. It was found that QN/QD moieties play a dominant role in the overall enantioseparation process of Fmoc-amino acids accompanied by the synergistic effect of β-CD moiety, which lead to the different enantioseparation of β-CD-QN-based CSP and β-CD-QD-based CSP. Furthermore, new CSPs retain extraordinary enantioseparation of cyclodextrin-based CSP for some neutral analytes on normal phase and even exhibit better enantioseparation than the corresponding β-CD-based CSP for certain samples.

AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS, SALTS THEREOF, AND METHODS OF SYNTHESIS THEREOF

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Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands

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New structurally simple indolic non peptidic HIV Protease inhibitors were synthesized from (S)-glycidol by regioselective methods. Following the concept of targeting the protein backbone, different substitution patterns were introduced onto the common stereodefined isopropanolamine core modifying the type of functional group on the indole, the position of the functional group on the indole and the type of the nitrogen containing group (sulfonamides or perhydroisoquinoline), alternatively. The systematic study on in vitro inhibition activity of such compounds confirmed the general beneficial effect of the 5-indolyl substituents in presence of arylsulfonamide moieties, which furnished activities in the micromolar range. Preliminary docking analysis allowed to identify several key features of the binding mode of such compounds to the protease.

Synthesis of the calcilytic ligand NPS 2143

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Synthesis of 5-oxyquinoline derivatives for reversal of multidrug resistance

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