- First structure-activity relationship study on dopamine D3 receptor agents with N-[4-(4-Arylpiperazin-1-yl)butyl]-arylcarboxamide structure
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Structure-affinity relationships of N-[4-(4-arylpiperazin-1-yl)butyl] arylcarboxamides as D3 receptor ligands have been well characterized but not structure-activity relationships. In a first attempt to clarify this issue, seven 1-(2,3-dichloro
- Leopoldo, Marcello,Lacivita, Enza,Colabufo, Nicola A.,Contino, Marialessandra,Berardi, Francesco,Perrone, Roberto
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- RADIOLABELED COMPOUNDS AND METHODS THEREOF
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The present invention relates to radiodiagnostic compounds, methods of making those compounds, and methods of use thereof as imaging agents for preferably a HA serotonin 5-HT1A receptor for use in PET or SPECT, preferably PET. Compositions comprising an imaging-effective amount of radiolabeled compounds are also disclosed. The present invention also relates to non-radiolabeled compounds, methods of making those compounds, and methods of use thereof to treat various neurological and/or psychiatric disorders.
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Page/Page column 131
(2011/12/14)
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- Arylpiperazine Derivatives as High-Affinity 5-HT1A Serotonin Ligands
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Although simple arylpiperazines are commonly considered to be moderately selective for 5-HT1B serotonin binding sites, N4-substitution of such compounds can enhance their affinity for 5-HT1A sites and/or decrease their affinity for 5
- Glennon, Richard A.,Naiman, Noreen A.,Lyon, Robert A.,Titeler, Milt
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p. 1968 - 1971
(2007/10/02)
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