115338-28-8Relevant articles and documents
First structure-activity relationship study on dopamine D3 receptor agents with N-[4-(4-Arylpiperazin-1-yl)butyl]-arylcarboxamide structure
Leopoldo, Marcello,Lacivita, Enza,Colabufo, Nicola A.,Contino, Marialessandra,Berardi, Francesco,Perrone, Roberto
, p. 7919 - 7922 (2005)
Structure-affinity relationships of N-[4-(4-arylpiperazin-1-yl)butyl] arylcarboxamides as D3 receptor ligands have been well characterized but not structure-activity relationships. In a first attempt to clarify this issue, seven 1-(2,3-dichloro
Arylpiperazine Derivatives as High-Affinity 5-HT1A Serotonin Ligands
Glennon, Richard A.,Naiman, Noreen A.,Lyon, Robert A.,Titeler, Milt
, p. 1968 - 1971 (2007/10/02)
Although simple arylpiperazines are commonly considered to be moderately selective for 5-HT1B serotonin binding sites, N4-substitution of such compounds can enhance their affinity for 5-HT1A sites and/or decrease their affinity for 5