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8-Bromo-5-chloroquinoline is a specialized chemical compound belonging to the class of quinolines and derivatives. It features a structurally complex heterocyclic quinoline moiety, which consists of a benzene ring fused to a pyridine ring, with notable bromine and chlorine components. 8-Bromo-5-chloroquinoline is utilized in various chemical reactions and serves as a fundamental reagent in laboratory settings, with its properties largely dependent on its structural composition. Due to its reactivity, it must be handled with care to mitigate potential risks.

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  • 1154741-20-4 Structure
  • Basic information

    1. Product Name: 8-Bromo-5-chloroquinoline
    2. Synonyms: 8-Bromo-5-chloroquinoline;5-chloro-8-broMoquinoline;8-Bromo-5-chloro-1-azanaphthalene
    3. CAS NO:1154741-20-4
    4. Molecular Formula: C9H5BrClN
    5. Molecular Weight: 242.4997
    6. EINECS: -0
    7. Product Categories: N/A
    8. Mol File: 1154741-20-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 325.7±22.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.673
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 1.24±0.29(Predicted)
    10. CAS DataBase Reference: 8-Bromo-5-chloroquinoline(CAS DataBase Reference)
    11. NIST Chemistry Reference: 8-Bromo-5-chloroquinoline(1154741-20-4)
    12. EPA Substance Registry System: 8-Bromo-5-chloroquinoline(1154741-20-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1154741-20-4(Hazardous Substances Data)

1154741-20-4 Usage

Uses

Used in Chemical Synthesis:
8-Bromo-5-chloroquinoline is used as a key intermediate in the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries. Its unique structural features, including the bromine and chlorine atoms, facilitate targeted chemical reactions, enabling the creation of a wide range of derivative compounds with specific therapeutic or functional properties.
Used in Laboratory Research:
As a fundamental reagent, 8-Bromo-5-chloroquinoline is employed in laboratory research to explore its chemical properties, reactivity, and potential applications. Researchers utilize this compound to study reaction mechanisms, investigate its interactions with other molecules, and develop new synthetic methodologies.
Used in Medicinal Chemistry:
8-Bromo-5-chloroquinoline is used as a building block in the design and development of novel pharmaceutical agents. Its quinoline core is a common structural motif in many bioactive compounds, making it a valuable component in the creation of new drugs with potential therapeutic benefits.
Used in Agrochemical Development:
In the agrochemical industry, 8-Bromo-5-chloroquinoline serves as a precursor for the synthesis of various pesticides and insecticides. Its unique chemical properties allow for the development of effective crop protection agents that can target specific pests while minimizing environmental impact.
Used in Material Science:
8-Bromo-5-chloroquinoline's structural characteristics make it a candidate for the development of new materials with specific properties, such as electronic, optical, or catalytic functions. Its potential applications in material science include the creation of organic semiconductors, sensors, or catalysts for various industrial processes.
Used in Environmental Analysis:
Due to its reactivity and unique chemical properties, 8-Bromo-5-chloroquinoline can be employed in environmental analysis for the detection and monitoring of pollutants or contaminants. Its use in analytical chemistry may involve the development of new methods for the identification and quantification of hazardous substances in various environmental matrices.
Used in Educational Purposes:
8-Bromo-5-chloroquinoline is utilized in educational settings to teach students about the properties and reactions of heterocyclic compounds. It serves as a practical example of a quinoline derivative, helping students understand the principles of organic chemistry and the importance of structural composition in determining a compound's properties and reactivity.

Check Digit Verification of cas no

The CAS Registry Mumber 1154741-20-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,4,7,4 and 1 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1154741-20:
(9*1)+(8*1)+(7*5)+(6*4)+(5*7)+(4*4)+(3*1)+(2*2)+(1*0)=134
134 % 10 = 4
So 1154741-20-4 is a valid CAS Registry Number.

1154741-20-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-Bromo-5-chloroquinoline

1.2 Other means of identification

Product number -
Other names 8-Bromo-5-chloro-1-azanaphthalene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1154741-20-4 SDS

1154741-20-4Downstream Products

1154741-20-4Relevant articles and documents

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

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Page/Page column 91-92, (2009/06/27)

Compounds of formula (I): wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

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Page/Page column 101-102, (2009/06/27)

Compounds of formula (I): wherein c, X, Y, R2, R4 and R5 are defined herein, are useful as inhibitors of HIV replication.

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

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Page/Page column 98-99, (2009/06/27)

The present invention relates to compounds of formula (I) wherein c, X, Y, R2, R3, R4 and R6 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

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Page/Page column 104, (2009/06/27)

Compounds of formula I : wherein c, R2, R3, R4, R5, R6, R7 and R8 are defined herein, are useful as inhibitors of HIV replication.

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