115581-09-4

Basic information

• Product Name: 5-Bromo-6-quinolinol
• Synonyms: 5-Bromo-6-quinolinol;5-BroMoquinolin-6-ol
• CAS NO: 115581-09-4
• Molecular Formula: C₉H₆BrNO
• Molecular Weight: 224.05404
• Mol File: 115581-09-4.mol

Chemical Properties

• Melting Point: 229 °C (decomp)
• Boiling Point: 327.9±22.0 °C(Predicted)
• Appearance: /
• Density: 1.705±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.34±0.40(Predicted)
• CAS DataBase Reference: 5-Bromo-6-quinolinol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-6-quinolinol(115581-09-4)
• EPA Substance Registry System: 5-Bromo-6-quinolinol(115581-09-4)

Safety Data

• Hazardous Substances Data: 115581-09-4(Hazardous Substances Data)

Usage

Chemical Properties

Solid

Upstream product

• 5847-59-6 2-bromo-4-nitrophenol 
• 56-81-5 glycerol 
• 123-30-8 4-amino-phenol 
• 25726-54-9 6-methoxyquinoline hidrochloride 
• 580-16-5 6-hydroxyquinoline 

Downstream Products

• 89-00-9 Pyridine-2,3-dicarboxylic acid 

Relevant articles and documents

COMPOSITIONS FOR THE TREATMENT OF BRAIN TUMORS

The instant invention describes pharmaceutical compositions and dosing regimens comprising radiation therapy and seviteronel with or without dexamethasone, and methods of treating diseases, disorders or symptoms thereof.

A Dearomatization/Debromination Strategy for the [4+1] Spiroannulation of Bromophenols with α,β-Unsaturated Imines

A novel [4+1] spiroannulation of o- & p-bromophenols with α,β-unsaturated imines has been developed for the direct synthesis of a new family of azaspirocyclic molecules. Notably, several other halophenols (X=Cl, I) were also applicable for this transformation. Moreover, a catalytic asymmetric version of the reaction was realized with 1-bromo-2-naphthols by using a chiral ScIII/Py-Box catalyst. Mechanistic studies revealed that this domino reaction proceeded through electrophile-triggered dearomatization of phenol derivatives at their halogenated positions and followed by halogen-displacement with N-nucleophiles via a radical-based SRN1 mechanism.

COMPOSITIONS FOR THE TREATMENT OF BRAIN TUMORS

The instant invention describes pharmaceutical compositions and dosing regimens comprising seviteronel and/or dexamethasone, and methods of treating diseases, disorders symptoms thereof.

Synthesis of 2-arylbenzofuran-3-carbaldehydes: via an organocatalytic [3+2] annulation/oxidative aromatization reaction

A novel organocatalytic [3+2] annulation/oxidative aromatization reaction of enals with 2-halophenols or β-naphthols is reported. This process enables chemo- and regioselective access to 2-arylbenzofuran-3-carbaldehydes without the use of transition metals or strong oxidants. Preliminary mechanistic studies reveal that an unprecedented, organocatalytic, direct α-arylation pathway is involved.

Modular Assembly of Spirocarbocyclic Scaffolds through Pd0-Catalyzed Intermolecular Dearomatizing [2+2+1] Annulation of Bromonaphthols with Aryl Iodides and Alkynes

A novel palladium(0)-catalyzed dearomatizing [2+2+1] spiroannulation of 1-bromo-2-naphthols with aryl iodides and alkynes was developed for the rapid assembly of spiro[indene-1,1′-naphthalen]-2′-ones. This three-component cascade reaction was realized thr

METALLOENZYME INHIBITOR COMPOUNDS

The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

A contribution to the erythroquine and thalleioquine reaction

The 8,8′-biquinoline-5,5′-diones 2A are formed by the erythroquine and thalleioquine reaction from the 6-methoxyquinolines 1 as model compounds. The red substances 2A react with hydrochloric acid to yield the yellow biquinolinedihydrochlorides 3. The structure of 3b dihydrate is determined by X-ray crystal analysis. The redox properties of 2A are investigated by voltammetric methods.