115891-10-6

Basic information

• Product Name: 2-(2,4-Difluoro-phenylamino)-nicotinic acid
• Synonyms: 2-(2,4-Difluoro-phenylamino)-nicotinic acid
• CAS NO: 115891-10-6
• Molecular Formula: C₁₂H₈F₂N₂O₂
• Molecular Weight: 250
• Mol File: 115891-10-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2,4-Difluoro-phenylamino)-nicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-Difluoro-phenylamino)-nicotinic acid(115891-10-6)
• EPA Substance Registry System: 2-(2,4-Difluoro-phenylamino)-nicotinic acid(115891-10-6)

Safety Data

• Hazardous Substances Data: 115891-10-6(Hazardous Substances Data)

Upstream product

• 367-25-9 2,4-difluorophenylamine 
• 115891-30-0 methyl 2-(2,4-difluorophenylamino)nicotinate 
• 446-26-4 methyl 2-fluoro-3-pyridinecarboxylate 
• 2942-59-8 2-chloronicotinic acid 

Downstream Products

• 115891-53-7 2-[(2,4-Difluoro-phenyl)-hexanoyl-amino]-nicotinic acid methyl ester 
• 115891-30-0 methyl 2-(2,4-difluorophenylamino)nicotinate 

Relevant articles and documents

TRPA1 MODULATORS

Compounds of formula la or lb, wherein R1 and R2 are as defined in the claims, exhibit TRPA1 activity and are thus useful as TRPA1 modulators.

Antiallergy Agents. 1. Substituted 1,8-Naphthyridin-2(1H)-ones as Inhibitors of SRS-A Release

A novel class of antiallergy agents, the substituted 1,8-naphthyridin-2(1H)-ones, is described.The present compounds are orally active, potent inhibitors of allergic and nonallergic bronchospasm in animal models.Structure-activity studies of the lead compound in this sereis, 1-phenyl-3-n-butyl-4-hydroxynaphthyridin-2(1H)-one (11), identified three compounds of interest, 1-phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (12), 1-(3'-chlorophenyl)-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (87), and 1-(3'-methoxyphenyl)-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (89).The mechanism of antiallergy activity may involve inhibition of the release of the sulfidopeptide leukotrienes. 1-Phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one, Sch 33303 (12), was selected for preclinical development as an antiallergy agent.