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2942-59-8

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2942-59-8 Usage

Description

2-Chloronicotinic acid, a white to cream powder with a melting point above 175°C, is a chemical compound known for its insolubility in water and solubility in organic solvents such as benzene and toluene. It serves as a versatile intermediate in the synthesis of various pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
2-Chloronicotinic acid is used as a pharmaceutical intermediate for the synthesis of anti-inflammatory and analgesic drugs like pralofen. It plays a crucial role in the production of mefenamic acid and niflumic acid, which are widely used for their therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloronicotinic acid is utilized as an intermediate in the development of herbicides such as nicosulfuron and diflufenican. These herbicides are essential for effective weed control in agricultural practices.
Used in Chemical Synthesis:
2-Chloronicotinic acid is also employed in the preparation of 4-thiazolidinone derivatives and Schiff bases, which exhibit antimicrobial activity. This application highlights its significance in the development of new compounds with potential applications in various industries, including pharmaceuticals and materials science.

Preparation

Chloronicotinic acid was synthesized from nicotinic acid by oxidation by H2O2 and then chlorinationby POCl3 and PCl5 in a yield of 87.5%.Synthesis of 2-chloronicotinic acid: Pour chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, and heat the mixed solution. The reaction was carried out at 100-105°C for 1-1.5 h, and the reaction mixture was stirred for 30 min after the reaction mixture was transparent, and phosphorus oxychloride was removed under reduced pressure. The obtained residue was cooled to room temperature, and water was added to obtain the finished product of 2-chloronicotinic acid.

Check Digit Verification of cas no

The CAS Registry Mumber 2942-59-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,4 and 2 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2942-59:
(6*2)+(5*9)+(4*4)+(3*2)+(2*5)+(1*9)=98
98 % 10 = 8
So 2942-59-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H4ClNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H,9,10)/p-1

2942-59-8 Well-known Company Product Price

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  • CAS number
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  • Alfa Aesar

  • (A17082)  2-Chloronicotinic acid, 99%   

  • 2942-59-8

  • 10g

  • 181.0CNY

  • Detail
  • Alfa Aesar

  • (A17082)  2-Chloronicotinic acid, 99%   

  • 2942-59-8

  • 50g

  • 714.0CNY

  • Detail
  • Alfa Aesar

  • (A17082)  2-Chloronicotinic acid, 99%   

  • 2942-59-8

  • 250g

  • 2928.0CNY

  • Detail
  • Sigma-Aldrich

  • (Y0000825)  NiflumicacidimpurityA  European Pharmacopoeia (EP) Reference Standard

  • 2942-59-8

  • Y0000825

  • 1,880.19CNY

  • Detail
  • USP

  • (1274629)  FlunixinRelatedCompoundA  United States Pharmacopeia (USP) Reference Standard

  • 2942-59-8

  • 1274629-15MG

  • 14,500.98CNY

  • Detail
  • Aldrich

  • (150339)  2-Chloropyridine-3-carboxylicacid  99%

  • 2942-59-8

  • 150339-10G

  • 270.27CNY

  • Detail
  • Aldrich

  • (150339)  2-Chloropyridine-3-carboxylicacid  99%

  • 2942-59-8

  • 150339-50G

  • 1,081.08CNY

  • Detail

2942-59-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloronicotinic acid

1.2 Other means of identification

Product number -
Other names 2-chloro-nicotinic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2942-59-8 SDS

2942-59-8Synthetic route

2 chloro-3-methylpyridine
18368-76-8

2 chloro-3-methylpyridine

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With ozone; acetic acid at 20℃; for 5h; Reagent/catalyst; Temperature;98%
With N-hydroxyphthalimide; oxygen; cobalt(III) acetylacetonate In acetonitrile at 80℃; under 7500.75 Torr; for 18h; Reagent/catalyst; Temperature; Autoclave;94.1%
With permanganate(VII) ion
2-chloro-3-ethylpyridine
96440-05-0

2-chloro-3-ethylpyridine

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With sodium acetate; ozone; acetic acid at 20℃; for 5h; Temperature; Reagent/catalyst;98%
With potassium permanganate; water
2-chloro-3-isopropylpyridine

2-chloro-3-isopropylpyridine

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With iron(II) acetate; ozone; acetic acid at 100℃; Reagent/catalyst; Temperature;98%
2-chloro-3-(dichloromethyl)-pyridine

2-chloro-3-(dichloromethyl)-pyridine

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With 10% Ru/C; oxygen; sodium carbonate In tetrahydrofuran at 140℃; under 22502.3 - 30003 Torr; for 4h; Catalytic behavior; Temperature; Solvent; Pressure; Autoclave; Green chemistry;95.4%
ethyl 2-chloronicotinate
1452-94-4

ethyl 2-chloronicotinate

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With sodium hydroxide at 80℃; for 2h; Temperature;95.2%
With sodium hydroxide In methanol; water at 75℃;
2-chloro-3-(chloromethyl)pyridine
89581-84-0

2-chloro-3-(chloromethyl)pyridine

acetic acid
64-19-7

acetic acid

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With sodium nitrite In dimethyl sulfoxide at 20℃; for 8h; Temperature; Solvent;95.1%
2-Chloronicotinoyl chloride
49609-84-9

2-Chloronicotinoyl chloride

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With water at 0 - 5℃; for 0.5h; pH=1.5; Alkaline conditions; Green chemistry;92%
In water
Pyridine-2,3-dicarboxylic acid
89-00-9

Pyridine-2,3-dicarboxylic acid

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With potassium permanganate; chlorine In water at 85 - 90℃; Reagent/catalyst; Solvent;91%
2-chloro-3-(trichloromethyl)-pyridine
72648-12-5

2-chloro-3-(trichloromethyl)-pyridine

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With sulfuric acid; lithium acetate; water; silver; fluorosulphonic acid; acetic acid In methanol at 55 - 60℃; Electrolysis;91%
With water
nicotinic acid
59-67-6

nicotinic acid

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
Stage #1: nicotinic acid With dihydrogen peroxide; acetic acid In toluene Reflux;
Stage #2: With phosphorus pentachloride; trichlorophosphate In toluene Reflux;
90%
Multi-step reaction with 3 steps
1: molybdic acid; dihydrogen peroxide / water / 3 h / 92 - 95 °C / Green chemistry
2: trichlorophosphate; triethylamine / 6 h / 10 - 100 °C / Green chemistry
3: water / 0.5 h / 0 - 5 °C / pH 1.5 / Alkaline conditions; Green chemistry
View Scheme
2-chloro-3-pyridinecarbonitrile
6602-54-6

2-chloro-3-pyridinecarbonitrile

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With water; sodium hydroxide for 3h; Reflux;90%
With sulfuric acid at 100℃; for 10h;88%
With water; sodium chloride; sodium hydroxide at 90℃; Reagent/catalyst; Temperature;
2-chloro-3-vinylpyridine
1033125-18-6

2-chloro-3-vinylpyridine

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With zinc diacetate; ozone In ethanol at 100℃;87%
2-chloro-3-tert-butylpyridine

2-chloro-3-tert-butylpyridine

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With zinc diacetate; ozone In acetonitrile at 100℃;85%
3-cyanopyridine N-oxide
14906-64-0

3-cyanopyridine N-oxide

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With bis(trichloromethyl) carbonate In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide for 0.0833333h; Solvent; Reagent/catalyst; Time; Reflux; Large scale; Green chemistry;68.6%
Nicotinic acid N-oxide
2398-81-4

Nicotinic acid N-oxide

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With triethylamine; trichlorophosphate at 100℃; for 4h;65%
carbon monoxide
201230-82-2

carbon monoxide

2-chloro-3-iodopyridine
78607-36-0

2-chloro-3-iodopyridine

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With water; palladium diacetate; triethylamine; triphenylphosphine In 1,4-dioxane at 110℃; under 11251.1 Torr; for 2h; Flow reactor;57%
(2-chloropyrid-3-yl)methanol
42330-59-6

(2-chloropyrid-3-yl)methanol

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With 3,5-Lutidine; 4-acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl; sodium persulfate; tris(2,2'‐bipyridine)ruthenium(II) hexafluorophosphate In water; acetonitrile at 20℃; for 48h; Sealed tube; Irradiation;24%
2-hydroxy-3-carboxypyridine
609-71-2

2-hydroxy-3-carboxypyridine

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With phosphorus pentachloride; trichlorophosphate
With sodium hydroxide; trichlorophosphate In toluene
2-chloro-3-pyridinecarbonitrile
6602-54-6

2-chloro-3-pyridinecarbonitrile

glycine
56-40-6

glycine

A

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

B

N-(3-carboxamido-2-pyridyl)glycine
74149-43-2

N-(3-carboxamido-2-pyridyl)glycine

Conditions
ConditionsYield
With sodium carbonate In water for 12h; Heating;A n/a
B 1.4 g
Nicotinic acid N-oxide
2398-81-4

Nicotinic acid N-oxide

A

6-Chloro-3-pyridinecarboxylic acid
5326-23-8

6-Chloro-3-pyridinecarboxylic acid

B

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With phosphorus pentachloride; trichlorophosphate
Nicotinic acid N-oxide
2398-81-4

Nicotinic acid N-oxide

A

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

B

1-(5-Carboxy-2-pyridyl)-2-pyridon-3-carbonsaeure
117638-64-9

1-(5-Carboxy-2-pyridyl)-2-pyridon-3-carbonsaeure

Conditions
ConditionsYield
With trichlorophosphate In N,N-dimethyl-formamide Yield given;
α-chloro-nicotine

α-chloro-nicotine

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

2-oxy-nicotinic acid

2-oxy-nicotinic acid

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With phosphorus pentachloride; trichlorophosphate at 140℃; Zersetzen des Reaktionsprodukts mit Wasser;
nicotinic acid-1-oxide

nicotinic acid-1-oxide

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With phosphorus pentachloride; trichlorophosphate
(S)-2'-chloro-1,2,3,4,5,6-hexahydro-<2,3'>bipyridyl

(S)-2'-chloro-1,2,3,4,5,6-hexahydro-<2,3'>bipyridyl

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With potassium permanganate
2-<2-oxo-1,2-dihydro-pyridine-3-carbonylimino>-2H-<1,2'>bipyridyl-3'-carboxylic acid

2-<2-oxo-1,2-dihydro-pyridine-3-carbonylimino>-2H-<1,2'>bipyridyl-3'-carboxylic acid

A

5H-dipyrido<1,2-a:3',2'>pyrimidin-5-one
106531-39-9

5H-dipyrido<1,2-a:3',2'>pyrimidin-5-one

B

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
With phosphorus pentachloride; trichlorophosphate
Nicotinic acid N-oxide
2398-81-4

Nicotinic acid N-oxide

phosphorus pentachloride
10026-13-8, 874483-75-7

phosphorus pentachloride

A

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

B

4-chloronicotinic acid
10177-29-4

4-chloronicotinic acid

nicotinic acid-1-oxide

nicotinic acid-1-oxide

A

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

B

4-chloronicotinic acid
10177-29-4

4-chloronicotinic acid

Conditions
ConditionsYield
With phosphorus pentachloride; trichlorophosphate
ethyl 2-chloro-2-cyano-5-oxopentanoate
152361-99-4

ethyl 2-chloro-2-cyano-5-oxopentanoate

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 65 percent / PCl3, HCl(g) / dimethylformamide; toluene / 1.) 60 deg C, 30 min; 2.) 90 deg C, 1.5 h
2: NaOH / methanol; H2O / 75 °C
View Scheme
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

methyl 2-chloropyridine-3-carboxylate
40134-18-7

methyl 2-chloropyridine-3-carboxylate

Conditions
ConditionsYield
In methanol at -15℃; for 4h;100%
In methanol; diethyl ether; ethanol84%
78%
With methanol; diethyl ether
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

2-Chloronicotinoyl chloride
49609-84-9

2-Chloronicotinoyl chloride

Conditions
ConditionsYield
With thionyl chloride for 3h; Heating;100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 25℃; for 3h; Inert atmosphere;100%
With thionyl chloride for 3h; Heating;99%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide
139756-02-8

4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

N-(5-carbamoyl-1-methyl-3-propyl-1H-pyrazol-4-yl)-2-chloronicotinamide
1370409-73-6

N-(5-carbamoyl-1-methyl-3-propyl-1H-pyrazol-4-yl)-2-chloronicotinamide

Conditions
ConditionsYield
With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In 1,2-dichloro-ethane at 120℃; for 0.333333h; Microwave irradiation;100%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

methyl 3-amino-5-ethoxybenzoate
706792-04-3

methyl 3-amino-5-ethoxybenzoate

methyl 3-(2-chloronicotineamido)-5-ethoxybenzoate

methyl 3-(2-chloronicotineamido)-5-ethoxybenzoate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; Large scale;100%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

ethylamine
75-04-7

ethylamine

2-(ethylamino)-3-pyridine carboxylic acid
669087-25-6

2-(ethylamino)-3-pyridine carboxylic acid

Conditions
ConditionsYield
at 120℃; for 4h;99.7%
at 120℃; for 4h; Sealed vessel;99.7%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

C12H6Cl2N2O3
75910-09-7

C12H6Cl2N2O3

Conditions
ConditionsYield
With 1-ethyl-piperidine; N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride In tetrahydrofuran at 20℃; for 0.666667h;99%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

3-bromo-fluorophenylmercaptan

3-bromo-fluorophenylmercaptan

Conditions
ConditionsYield
In N,N-dimethyl-formamide; trichlorophosphate99%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

methyl 2-chloropyridine-3-carboxylate
40134-18-7

methyl 2-chloropyridine-3-carboxylate

Conditions
ConditionsYield
In tetrahydrofuran; methanol; hexane at 20℃; for 1.5h;99%
In methanol; hexanes; toluene at 20℃;85.42%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

1-(4,4'-dichloro-benzhydryl)-piperazine
27469-61-0

1-(4,4'-dichloro-benzhydryl)-piperazine

(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)(2-chloropyridin-3-yl)methanone

(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)(2-chloropyridin-3-yl)methanone

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;99%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

methylamine
74-89-5

methylamine

2-(methylamino)pyridine-3-carboxylic acid
32399-13-6

2-(methylamino)pyridine-3-carboxylic acid

Conditions
ConditionsYield
In water at 140℃; for 1.5h; Reactivity; Concentration; Temperature; Time; Microwave irradiation; Biotage Initiator;98%
With sodium hydroxide In methanol at 90℃; for 48h; Temperature; Solvent; Autoclave;93.8%
In water at 120℃; for 15h; sealed tube;56%
With pyridine; toluene-4-sulfonic acid In water Heating;
In ethanol at 80℃; for 80h; Autoclave;
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

N-methyl-1H-benzo[d]imidazol-2-amine
17228-38-5

N-methyl-1H-benzo[d]imidazol-2-amine

5,6-dihydro-6-methyl-5-oxopyrido<3',2':5,6>pyrimido<1,2-a>benzimidazole

5,6-dihydro-6-methyl-5-oxopyrido<3',2':5,6>pyrimido<1,2-a>benzimidazole

Conditions
ConditionsYield
With Ullmann copper; potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 170℃; for 5h;98%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

ethanol
64-17-5

ethanol

ethyl 2-chloronicotinate
1452-94-4

ethyl 2-chloronicotinate

Conditions
ConditionsYield
Stage #1: 2-chloronicotinic acid With thionyl chloride
Stage #2: ethanol
98%
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide for 4h;95%
With sulfuric acid for 2h; Reflux;79%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

methyl 2-chloropyridine-3-carboxylate
40134-18-7

methyl 2-chloropyridine-3-carboxylate

Conditions
ConditionsYield
With thionyl chloride; triethylamine In methanol; toluene98%
Multi-step reaction with 2 steps
1: SOCl2 / 2.5 h / Heating
2: Et3N / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride / 2 h / Heating
2: 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: SOCl2 / benzene / 3 h / Heating
2: 0.33 h / Heating
View Scheme
With thionyl chloride In methanol
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

ethyl iodide
75-03-6

ethyl iodide

ethyl 2-chloronicotinate
1452-94-4

ethyl 2-chloronicotinate

Conditions
ConditionsYield
With potassium carbonate In N-methyl-acetamide; water98%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 72h;
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

4-Ethoxyaniline
156-43-4

4-Ethoxyaniline

2-[(4-ethoxyphenyl)amino]pyridine-3-carboxylic acid
4394-10-9

2-[(4-ethoxyphenyl)amino]pyridine-3-carboxylic acid

Conditions
ConditionsYield
With potassium carbonate In water at 150℃; for 1.5h; Green chemistry;98%
With potassium carbonate In water at 150℃; for 1h; Microwave irradiation;86%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

1-(2-chloronicotinoyl)piperazine hydrochloride

1-(2-chloronicotinoyl)piperazine hydrochloride

Conditions
ConditionsYield
Stage #1: 2-chloronicotinic acid With thionyl chloride In dichloromethane at 0 - 50℃; for 4h; Reflux;
Stage #2: 1-t-Butoxycarbonylpiperazine With triethylamine In dichloromethane for 1h;
Stage #3: With hydrogenchloride In ethanol for 1h; Reflux;
98%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

2-methyl-3-trifluoromethylaniline
54396-44-0

2-methyl-3-trifluoromethylaniline

flunixin
38677-85-9

flunixin

Conditions
ConditionsYield
With perfluorosulfonic acid resin In water at 65 - 70℃; for 2.5h; Temperature; Industrial scale;97.1%
With potassium hydroxide; toluene-4-sulfonic acid In water83%
With pyridine; toluene-4-sulfonic acid In water Reflux;73%
With toluene-4-sulfonic acid; copper(II) oxide; sodium hydroxide In 1,2-dimethoxyethane; water at 45℃; for 0.6h; Reagent/catalyst; Temperature;
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

thiophenol
108-98-5

thiophenol

2-(phenylthio)nicotinic acid
35620-72-5

2-(phenylthio)nicotinic acid

Conditions
ConditionsYield
With potassium carbonate In water at 180℃; for 2h;97%
at 190℃;
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

3-chloro-aniline
108-42-9

3-chloro-aniline

2-<(3-chlorophenyl)amino>-3-pyridinecarboxylic acid
57978-41-3

2-<(3-chlorophenyl)amino>-3-pyridinecarboxylic acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid In water for 4h; Reflux;97%
With potassium carbonate In water at 150℃; for 3h; Green chemistry;94%
With sodium iodide at 100 - 140℃; for 3h;94%
tert-butyl N-[(1s,4s)-4-aminocyclohexyl]carbamate
247570-24-7

tert-butyl N-[(1s,4s)-4-aminocyclohexyl]carbamate

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

syn-{4-[(2-chloro-pyridine-3-carbonyl)-amino]-cyclohexyl}-carbamic acid tert-butyl ester
834868-97-2

syn-{4-[(2-chloro-pyridine-3-carbonyl)-amino]-cyclohexyl}-carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: 2-chloronicotinic acid; oxalyl dichloride With N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 3.16667h;
Stage #2: tert-butyl N-[(1s,4s)-4-aminocyclohexyl]carbamate With N-ethyl-N,N-diisopropylamine In dichloromethane for 18h;
97%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

3-methylmercaptoaniline
1783-81-9

3-methylmercaptoaniline

2-(3-Methylsulfanyl-phenylamino)-nicotinic acid
115891-07-1

2-(3-Methylsulfanyl-phenylamino)-nicotinic acid

Conditions
ConditionsYield
96%
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

butan-1-ol
71-36-3

butan-1-ol

2-n-butoxypyridine-3-carboxylic acid
28355-23-9

2-n-butoxypyridine-3-carboxylic acid

Conditions
ConditionsYield
With sodium In ethyl acetate96%
Stage #1: butan-1-ol With sodium hydride In dimethyl sulfoxide at 0℃; for 0.5h;
Stage #2: 2-chloronicotinic acid In dimethyl sulfoxide at 20℃;
Stage #3: With hydrogenchloride In water; dimethyl sulfoxide
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

p-toluidine
106-49-0

p-toluidine

2-[(4-methylphenyl)amino]pyridine-3-carboxylic acid
60645-32-1

2-[(4-methylphenyl)amino]pyridine-3-carboxylic acid

Conditions
ConditionsYield
With potassium carbonate In water at 150℃; for 2.5h; Green chemistry;96%
With potassium carbonate In water at 150℃; for 1h; Microwave irradiation;81%
With pyridine; toluene-4-sulfonic acid In water; acetone at 70℃; for 8h;

2942-59-8Relevant articles and documents

-

Moehrle,Sieker

, p. 380,382 (1976)

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Combining photoredox catalysis and oxoammonium cations for the oxidation of aromatic alcohols to carboxylic acids

Nandi, Jyoti,Hutcheson, Ellen L.,Leadbeater, Nicholas E.

supporting information, (2020/12/25)

A methodology is reported for converting alcohols to the corresponding carboxylic acids. A dual catalytic system involving a merger of photoredox catalysis and 4-acetamido-TEMPO is employed to carry out this oxidation process.

Process for preparation of carboxylic acid by hydrolysis of nitrile compound

-

Paragraph 0024-0046, (2020/03/06)

The invention relates to the technical field of chemical preparation processes, in particular to a process for preparation of carboxylic acid by hydrolysis of a nitrile compound. The process includesthe steps of: 1) adding the nitrile compound into a saturated aqueous solution of salt, then adding alkali, and carrying out hydrolysis reaction to obtain a reaction solution; 2) adding acid into thereaction solution obtained in step 1), performing filtering after complete precipitation of crystals to obtain a solid mixture, and recycling the filtrate; and 3) separating the solid mixture obtainedin step 2) to obtain carboxylic acid. The method adopts the saturated aqueous solution of salt as the solvent, the nitrile compound is hydrolyzed under an alkaline condition, then acid is added for acidification, the generated salt crystals are precipitated out, the generated carboxylic acid is a solid insoluble in the solvent and is precipitated out at the same time, then filtering operation iscarried out, the generated filtrate is further used as the solvent for hydrolysis reaction of the nitrile compound, and the filtered solid is separated to obtain the salt and carboxylic acid.

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