1160-68-5

Basic information

• Product Name: 2,2'-Dithiobis-benzoic acid dihydrazide
• Synonyms: 2,2'-Dithiobis-benzoic acid dihydrazide
• CAS NO: 1160-68-5
• Molecular Formula: C₁₄H₁₄N₄O₂S₂
• Molecular Weight: 452.5112
• Mol File: 1160-68-5.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.47g/cm³
• CAS DataBase Reference: 2,2'-Dithiobis-benzoic acid dihydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-Dithiobis-benzoic acid dihydrazide(1160-68-5)
• EPA Substance Registry System: 2,2'-Dithiobis-benzoic acid dihydrazide(1160-68-5)

Safety Data

• Hazardous Substances Data: 1160-68-5(Hazardous Substances Data)

Usage

Uses

Used in Polymer Synthesis:
2,2'-Dithiobis-benzoic acid dihydrazide is used as a crosslinking agent for the synthesis of multifunctional polymers, contributing to the improvement of their mechanical properties. Its capacity to form stable cross-links with biopolymers makes it a valuable component in the development of advanced materials with enhanced structural integrity and performance.
Used in Biomedicine:
In the field of biomedicine, 2,2'-Dithiobis-benzoic acid dihydrazide is utilized for its potential applications in drug delivery systems. Its ability to cross-link with biopolymers is being explored to create novel systems that can improve the delivery and efficacy of therapeutic agents.
Used in Enzyme and Protein Stabilization:
2,2'-Dithiobis-benzoic acid dihydrazide also serves as a stabilizing agent for enzymes and proteins. Its crosslinking properties can potentially enhance the stability and shelf life of these biologically active molecules, which is crucial for their application in various industrial and medical processes.
Used in Materials Science:
Within materials science, 2,2'-Dithiobis-benzoic acid dihydrazide is applied as a chemical modifier to enhance the mechanical properties of polymers. This enhancement can lead to the creation of materials with improved durability, strength, and resistance to environmental factors, broadening their range of applications across different industries.

Upstream product

• 4892-02-8 Methyl thiosalicylate 
• 19602-82-5 2,2'-dithiodibenzoic acid dichloride 
• 5651-35-4 2-phenylbenzo[d]-1,3-oxathiin-4-one 
• 24611-43-6 2-mercaptobenzoic acid hydrazide 

Downstream Products

• 110195-42-1 2,2'-disulfanediyl-di-benzoic acid bis-(N'-acetyl-hydrazide) 

Relevant articles and documents

A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: The 2,2'-dithiobisbenzamides

As part of the National Cancer Institute's Drug Screening Program, a new class of antiretrovirals active against the human immunodeficiency virus HIV-1 has been identified, and the HIV-1 nucleocapsid protein NCp7 was proposed as the target of antiviral action. The 2,2'-dithiobis-[4'-(sulfamoyl)benzanilide] (3x) and the 2,2'-dithiobis(5-acetylamino)benzamide (10) represented the prototypic lead structures. A wide variety of 2,2'-dithiobisbenzamides were prepared and tested for anti-HIV-1 activity, cytotoxicity, and their ability to extrude zinc from the zinc fingers for NCp7. The structure-activity relationships demonstrated that the ability to extrude zinc from NCp7 resided in the 2,2'-dithiobisbenzamide core structure. The 3,3' and the 4,4' isomers were inactive. While many analogs based upon the core structure retained the zinc extrusion activity, the best overall anti-HIV-1 activity was only found in a narrow set of derivatives possessing carboxylic acid, carboxamide, or phenylsulfonamide functional groups. These functional groups were more important for reducing cytotoxicity than improving antiviral potency or activity vs NCp7. All of the compounds with antiviral activity also extruded zinc from NCp7. From this study several classes of low μM anti-HIV agents with simple chemical structures were identified as possible chemotherapeutic agents for the treatment of AIDS.

STUDIES ON ORGANOPHOSPHORUS COMPOUNDS. THIATION OF 3,1-BENZOXATHIAN-4-ONES. NEW ROUTES TO 1,2-BENZISOTHIAZOLE-3(2H)-THIONES AND 3H-1,2-BENZODITHIOL-3-IMINES

3,1-Benzoxathian-4-ones, 2, when heated with 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide, 1, or with P4S10 give one or more of the following products: 3,1-benzoxathian-4-thione, 3, 1,3-benzodithian-4-one, 4, 1,3-benzodithian-4-thion