Manganese(III)-mediated oxidative radical addition of malonates to 2-cyanoindoles
2-Cyanoindole and N-methyl-2-cyanoindole undergo manganese(III)-mediated radical addition with activated methylene and methine compounds. Products of the methylene addition underwent additional oxidation during the course of the reaction to furnish the corresponding acetoxy compounds. Several structures were confirmed by X-ray crystallography.
Lopchuk, Justin M.,Montgomery, William L.,Jasinski, Jerry P.,Gorjifard, Sayeh,Gribble, Gordon W.
p. 6142 - 6145
(2013/10/22)
Palladium-catalyzed cyanation of aryl and heteroaryl iodides with copper(i) cyanide
The palladium-catalyzed cyanation of aryl and heteroaryl iodides or bromides using copper(i) cyanide as a cyano group source afforded the corresponding aryl and heteroaryl cyanides in good yields.
Sakamoto, Takao,Ohsawa, Kazutoshi
p. 2323 - 2326
(2007/10/03)
Synthesis of heteroarenecarbonitriles by electrophilic cyanation; Reaction of metalated heteroarenes with p-toluenesulfonyl cyanide
Several heteroarenecarbonitriles (5) were synthesized in moderate yields from heteroarenes (3) through metalation, followed by electrophilic cyanation using p-toluenesulfonyl cyanide. Similarly, trimethylsilylheteroarenes (8) were converted to heteroarenecarbonitriles (5) in good yields by treatment with p-toluenesulfonyl cyanide.
A DIRECTED METALATION ROUTE TO THE ZWITTERIONIC INDOLE ALKALOIDS. SYNTHESIS OF SEMPERVIRINE
A synthesis protocol involving beta-lithiation of 2-(2-pyridinyl)indoles(45) and subsequent reaction with bromoacetaldehyde leads to the indoloquinolizine (1) ring system.Application of this methodology to 2-(2-pyridinyl)indole 17, which is prepared via Taylor-Boger triazine Diels-Alder annulation chemistry, affords the zwitterionic indole alkaloid sempervirine (3).
Gribble, Gordon W.,Barden, Timothy C.,Johnson, David A.
p. 3195 - 3202
(2007/10/02)
More Articles about upstream products of 116325-35-0