116355-84-1

Basic information

• Product Name: FUMONISIN B2
• Synonyms: 1,2,3-PROPANETRICARBOXYLIC ACID, 1,1'-[1-(12-AMINO-9,11-DIHYDROXY-2-METHYL-TRIDECYL)-2-(1-METHYLPENTYL)-1,2-ETHANE-DIYL]ESTER;1,2,3-PROPANETRICARBOXYLIC ACID, 1,1'-[1-(12-AMINO-4,11-DIHYDROXY-2-METHYL-TRIDECYL)-2-(1-METHYLPENTYL)-1,2-ETHANE-DIYL]ESTER;FUMONISIN B3;FUMONISIN B2;FUMONISIN B2, FUSARIUM MONILIFORME;FB2;1,2,3-propanetricarboxylicacid,1,1’-(1-(2-amino-9,11-dihydroxy-2-methyltridec;yl)-2-(1-methylpentyl)-1,2-ethanediyl)ester
• CAS NO: 116355-84-1
• Molecular Formula: C34H59NO14
• Molecular Weight: 705.83
• EINECS: 201-067-0
• Product Categories: Agro-Products;Heterocycles;Isotope Labeled Compounds;Enzyme InhibitorsEnzyme Inhibitors by Enzyme;Sphingosine acyltransferase;Core Bioreagents;R to;Research Essentials;Isotope Labelled Compounds;Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;antibiotic
• Mol File: 116355-84-1.mol

Chemical Properties

• Melting Point: <3200(dec)
• Boiling Point: 705.92°C (rough estimate)
• Flash Point: 6 °C
• Appearance: /
• Density: 1.2044 (rough estimate)
• Vapor Pressure: 7.57E-35mmHg at 25°C
• Refractive Index: 1.6630 (estimate)
• Storage Temp.: −20°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3?+-.0.23(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: FUMONISIN B2(CAS DataBase Reference)
• NIST Chemistry Reference: FUMONISIN B2(116355-84-1)
• EPA Substance Registry System: FUMONISIN B2(116355-84-1)

Safety Data

• Hazard Codes: T+,T,Xn,F
• Statements: 26/27/28-36/37/38-40-36-20/21/22-11
• Safety Statements: 22-36/37/39-45-36/37-16-26
• RIDADR: UN 2811 6.1/PG 1
• WGK Germany: 3
• RTECS: TZ8335000
• Hazardous Substances Data: 116355-84-1(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Industry:
Fumonisin B2 is used as a contact herbicide for producing desiccation and defoliation, aiding in the control of unwanted plant growth.
Used in Pharmaceutical Research:
Fumonisin B2 acts as an inhibitor of sphingosine N-acyltransferase, blocking the formation of ceramide from sphingosine. This property makes it a subject of interest in the study of ceramide biosynthesis and its potential applications in pharmaceutical research, particularly in the development of treatments for various diseases.
Used in Mycotoxin Research:
As a minor analogue of a family of potent mycotoxins, Fumonisin B2 is used in research to better understand the pharmacology of the fumonisins, with a focus on its effects on ceramide biosynthesis and its potential implications in animal toxicity and carcinogenicity.

Biochem/physiol Actions

Inhibitor of sphingosine N-acyltransferase. Blocks the formation of ceramide from sphingosine.

Safety Profile

Fumonisin B2, a mycotoxin produced by Fusariummoniliforme in a variety of cereals, is a potent inhibitor of sphingosine N-acyltransferase (ceramidesynthase), blocking sphingolipid de novo synthesis. Fumonisin (FB) is a mycotoxin, a structurally similar bidentate compound composed of different polyhydric alcohols and propionic tricarboxylic acids, of which fumonisin B1 (FB1), fumonisin B2 (FB2) and fumonisin B3 (FB3) are the main components of contaminated food and its products, and a potential trigger for cancer, and has been declared by the International Agency for Research on Cancer as The International Agency for Research on Cancer has declared fumonisins as "Class 2B" toxicants (possible carcinogens to humans).

InChI:InChI=1/C34H59NO14/c1-5-6-12-21(3)32(49-31(43)18-24(34(46)47)16-29(40)41)27(48-30(42)17-23(33(44)45)15-28(38)39)14-20(2)11-9-7-8-10-13-25(36)19-26(37)22(4)35/h20-27,32,36-37H,5-19,35H2,1-4H3,(H,38,39)(H,40,41)(H,44,45)(H,46,47)/t20-,21+,22-,23+,24+,25+,26-,27-,32+/m0/s1