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4-Bromo-5-chloro-2-fluoroaniline, also known as BCAF, is a chemical compound with the molecular formula C6H4BrClFN. It is a white crystalline solid with a high melting point and is sparingly soluble in water. BCAF is an important intermediate in the production of pharmaceuticals and agrochemicals, particularly in the synthesis of various pharmaceuticals and pesticides. It is known to be a potent inhibitor of the enzyme Myeloperoxidase, which has potential implications in the treatment of inflammatory diseases and cancer.

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  • 116369-24-5 Structure
  • Basic information

    1. Product Name: 4-Bromo-5-chloro-2-fluoroaniline
    2. Synonyms: 4-Bromo-5-chloro-2-fluoroaniline
    3. CAS NO:116369-24-5
    4. Molecular Formula: C6H4BrClFN
    5. Molecular Weight: 224.4580632
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 116369-24-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 258.9°C at 760 mmHg
    3. Flash Point: 110.4°C
    4. Appearance: /
    5. Density: 1.809g/cm3
    6. Vapor Pressure: 0.0134mmHg at 25°C
    7. Refractive Index: 1.61
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
    9. Solubility: N/A
    10. CAS DataBase Reference: 4-Bromo-5-chloro-2-fluoroaniline(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-Bromo-5-chloro-2-fluoroaniline(116369-24-5)
    12. EPA Substance Registry System: 4-Bromo-5-chloro-2-fluoroaniline(116369-24-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 116369-24-5(Hazardous Substances Data)

116369-24-5 Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-5-chloro-2-fluoroaniline is used as an intermediate in the synthesis of various pharmaceuticals for its potential role in the treatment of inflammatory diseases and cancer. Its ability to inhibit the enzyme Myeloperoxidase makes it a promising candidate for developing new therapeutic agents.
Used in Agrochemical Industry:
4-Bromo-5-chloro-2-fluoroaniline is used as an intermediate in the production of agrochemicals, specifically in the synthesis of various pesticides. Its versatile chemical properties allow for the development of effective and targeted pest control solutions.

Check Digit Verification of cas no

The CAS Registry Mumber 116369-24-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,3,6 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 116369-24:
(8*1)+(7*1)+(6*6)+(5*3)+(4*6)+(3*9)+(2*2)+(1*4)=125
125 % 10 = 5
So 116369-24-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H4BrClFN/c7-3-1-5(9)6(10)2-4(3)8/h1-2H,10H2

116369-24-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-bromo-5-chloro-2-fluoroaniline

1.2 Other means of identification

Product number -
Other names Benzenamine,4-bromo-5-chloro-2-fluoro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:116369-24-5 SDS

116369-24-5Relevant articles and documents

N-(HETEROARYL) QUINAZOLIN-2-AMINE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

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Page/Page column 42, (2021/04/30)

The present invention is directed to substituted certain N-(heteroaryl)quinazolin-2-amine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein J, R3, and R4, are as defined herein, which are potent inhib

THIADIAZOLE MODULATORS OF S1P AND METHODS OF MAKING AND USING

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, (2017/01/26)

The invention is directed to compounds of the formula: wherein each of the variables are defined herein, as well as methods of making and using the compounds as agonists of S1P1 and/or S1P5 for instance treating an autoimmune disease.

SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

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Paragraph 0370, (2016/05/02)

Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

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