cas 1165-38-4, 2,3-Seco-5-androstan-17-one-2,3-dicarboxylic acid | Articles data ｜lookchem

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1165-38-4

Articles about 1165-38-4Total 4 be found

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Steroidal nitrone inhibitors of 5α-reductase
This paper describes the rational design and synthesis of novel inhibitors of human steroid 5α-reductase. Steroidal nitrones were synthesised via an eight-step sequence from epiandrosterone and were tested for activity against type I and II 5α-reductase isozymes. Judicious placement of the nitrone into the steroid A-ring provided an effective and stable transition-state mimic of the postulated enolate intermediate involved in the conversion of testosterone into dihydrotestosterone.
Robinson, Andrea J.,DeLucca, Indawati,Drummond, Spencer,Boswell, George A.
p. 4801 - 4804
(2003)
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CYP11B, CYP17, AND/OR CYP21 INHIBITORS
Provided herein are inhibitors of CYP11B, CYP17, and/or CYP21 enzymes of Formula (Z), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), or (XVII). Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions. Formula (Z)
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Page/Page column 206

(2012/06/30)

NOVEL CYP17 INHIBITORS
Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.
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Page/Page column 110-111

(2011/08/04)

Preparation and transformations of steroidal butadiynes
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Gupta,Jones,Caspi
p. 1420 - 1427
(2007/10/09)

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Chemical Properties

Boiling Point: 537.2°Cat760mmHg
Flash Point:292.8°C
Density: 1.173g/cm³
Vapor Pressure: 5.71E-13mmHg at 25°C
Refractive Index: 1.52
PSA: 91.67000
LogP: 3.36370

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