- Efficient Route for the Synthesis of Diverse Heteroannelated 5-Cyanopyridines
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The new efficient, convenient protocol for the synthesis of heteroannelated 3-cyanopyridines and pyrimidines starting from diverse aminoheterocycles and 3,3-dimethoxy-2-formylpropionitrile sodium salt was elaborated. The advantages and improvements of the
- Mityuk, Andrey P.,Hrebonkin, Andrii,Lebed, Pavlo S.,Grabchuk, Galyna P.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.
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p. 2133 - 2141
(2021/02/22)
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- Pyridine-thiophene-based diketopyrrolopyrrole and polymer thereof
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The invention discloses a pyridine-thiophene-based diketopyrrolopyrrole polymer. The structure of the pyridine-thiophene-based diketopyrrolopyrrole polymer is shown as a formula I. The hole mobility of an organic field-effect transistor made from pyridine-thiophene-based diketopyrrolopyrrole serving as an organic semiconductor layer is 1.31*10cmVs, and the switching ratio is greater than 10 to 10; the pyridine-thiophene-based diketopyrrolopyrrole polymer has a very high application foreground in organic field-effect transistor devices. The formula (I) is shown in the description.
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- BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY
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A compound of formula (Ia) or (Ib) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of a histone deacetylase, and as such is useful in terepy, e.g. in the treatment of autoimmune disorders, mental disorders, neurodegenerative disorders, and hyperproliferative disorders.
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Page/Page column 110
(2017/07/14)
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- Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease
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The invention provides compounds of Formula I: 1where in W is 2These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful to treat diseases or conditions in which α7 is known to be involved.
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- α-vinylation of β-aminothiophene derivatives. Synthesis of 6- functionalized thieno[3,2-b]pyridines
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The acid-catalyzed reductive α-alkylation of β-aminothiophenes was applied to the N-(thien-3-yl)acetamide and alkyl N-(thien-3-yl)carbamates. Without reduction, β-amino α-vinylthiophenes were obtained when α-branched aldehydes were used. β-(3-Aminothien-2-yl)α,β-unsaturated ketones, esters and nitriles were also prepared from the corresponding α-functionalized acetals. These amines are intermediates in the formation of thieno[3,2- b]pyridines bearing a functional group at the β-position of the pyridine ring.
- Berkaoui, M'hamed,Outurquin, Francis,Paulmier, Claude
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p. 9055 - 9066
(2007/10/03)
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- Facile Synthesis of Annelated NADH Model Precursors
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A convenient route to γ-cyano fused pyridine derivatives, which are precursors of NADH models, is described.The method involves the reaction of 3,3-dimethoxy-2-formyl-propionitrile sodium salt (1) with amino derivatives of electron donating heterocyles le
- Benoit, R.,Dupas, G.,Bourguignon, J.,Queguiner, G.
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p. 1124 - 1126
(2007/10/02)
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