116538-95-5

Basic information

• Product Name: Thieno[3,2-b]pyridine-6-carbonitrile (9CI)
• Synonyms: Thieno[3,2-b]pyridine-6-carbonitrile (9CI);thieno[3,2-b]pyridine-6-carbonitrile
• CAS NO: 116538-95-5
• Molecular Formula: C8H4N2S
• Molecular Weight: 160.19576
• Product Categories: THIENOPYRIDINE
• Mol File: 116538-95-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 330.5±22.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• PKA: 1.52±0.40(Predicted)
• CAS DataBase Reference: Thieno[3,2-b]pyridine-6-carbonitrile (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[3,2-b]pyridine-6-carbonitrile (9CI)(116538-95-5)
• EPA Substance Registry System: Thieno[3,2-b]pyridine-6-carbonitrile (9CI)(116538-95-5)

Safety Data

• Hazardous Substances Data: 116538-95-5(Hazardous Substances Data)

Usage

General Description

Thieno[3,2-b]pyridine-6-carbonitrile (9CI) is a chemical compound with the molecular formula C8H4N2S. It is a heterocyclic compound that contains both sulfur and nitrogen atoms in its structure, giving it unique reactivity and properties. Thieno[3,2-b]pyridine-6-carbonitrile is commonly used as a building block in organic synthesis and drug discovery efforts, due to its potential pharmacological and biological activities. Thieno[3,2-b]pyridine-6-carbonitrile (9CI) is of interest in medicinal chemistry and drug development, particularly for its potential as a starting material for the synthesis of bioactive molecules. Its molecular structure and reactivity make it a valuable tool for the creation of new compounds with potential therapeutic applications. Thieno[3,2-b]pyridine-6-carbonitrile has diverse potential applications, making it an important compound in the field of organic chemistry and drug discovery.

Upstream product

• 25475-76-7 3-aminothiophene hydrochloride 
• 105161-33-9 sodium (E)-2-cyano-3,3-dimethoxy-prop-1-en-1-olate 
• 17721-06-1 3-aminothiophene 
• 75-09-2 dichloromethane 
• 57597-62-3 3,3-dimethoxypropionitrile 
• 212570-96-2 (Z)-3-(3-Amino-thiophen-2-yl)-acrylonitrile 
• 557-21-1 zinc(II) cyanide 
• 105161-33-9 3,3-dimethyloxy-2-formylpropionitrile sodium salt 
• 272-67-3 thieno[3,2-b]pyridine 
• 69627-02-7 thieno[3,2-b]pyridin-7(4H)-one 
• 7677-24-9 trimethylsilyl cyanide 
• 7424-91-1 methyl 3,3-dimethoxypropionate 

Downstream Products

• 117390-39-3 thieno<3,2-b>pyridine 6-carboxylic acid 

Relevant articles and documents

Efficient Route for the Synthesis of Diverse Heteroannelated 5-Cyanopyridines

The new efficient, convenient protocol for the synthesis of heteroannelated 3-cyanopyridines and pyrimidines starting from diverse aminoheterocycles and 3,3-dimethoxy-2-formylpropionitrile sodium salt was elaborated. The advantages and improvements of the

BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY

A compound of formula (Ia) or (Ib) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of a histone deacetylase, and as such is useful in terepy, e.g. in the treatment of autoimmune disorders, mental disorders, neurodegenerative disorders, and hyperproliferative disorders.

α-vinylation of β-aminothiophene derivatives. Synthesis of 6- functionalized thieno[3,2-b]pyridines

The acid-catalyzed reductive α-alkylation of β-aminothiophenes was applied to the N-(thien-3-yl)acetamide and alkyl N-(thien-3-yl)carbamates. Without reduction, β-amino α-vinylthiophenes were obtained when α-branched aldehydes were used. β-(3-Aminothien-2-yl)α,β-unsaturated ketones, esters and nitriles were also prepared from the corresponding α-functionalized acetals. These amines are intermediates in the formation of thieno[3,2- b]pyridines bearing a functional group at the β-position of the pyridine ring.