Internal Lewis acid coordination as a powerful tool to promote highly stereoselective alkylation of α-alkyl-β-hydroxy ketones with Grignard reagents
An efficient and highly diastereoselective protocol is described for the alkylation of β-hydroxy ketones that contain an α-stereocenter. This method is based on the preliminary transformation of the β-hydroxy group into a titanium alcoholate by means of t
Bartoli, Giuseppe,Bellucci, M. Cristina,Bosco, Marcella,Marcantoni, Enrico,Sambri, Letizia
p. 2154 - 2161
(2007/10/03)
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