116614-13-2Relevant academic research and scientific papers
Internal Lewis acid coordination as a powerful tool to promote highly stereoselective alkylation of α-alkyl-β-hydroxy ketones with Grignard reagents
Bartoli, Giuseppe,Bellucci, M. Cristina,Bosco, Marcella,Marcantoni, Enrico,Sambri, Letizia
, p. 2154 - 2161 (2007/10/03)
An efficient and highly diastereoselective protocol is described for the alkylation of β-hydroxy ketones that contain an α-stereocenter. This method is based on the preliminary transformation of the β-hydroxy group into a titanium alcoholate by means of t
