1167056-92-9

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-;6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid
• CAS NO: 1167056-92-9
• Molecular Formula: C8H5ClN2O2
• Molecular Weight: 196.5905
• Mol File: 1167056-92-9.mol

Chemical Properties

• Boiling Point: 416.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.67±0.1 g/cm3(Predicted)
• PKA: 0.27±0.20(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-(1167056-92-9)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-(1167056-92-9)

Safety Data

• Hazardous Substances Data: 1167056-92-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chlorois used as a key intermediate in the synthesis of biologically active compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications, making it a valuable asset in drug discovery and medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloromay serve as a precursor for the creation of novel agrochemicals. Its chemical properties could be harnessed to develop pesticides or other compounds that enhance crop protection and yield.
Used in Research and Development:
1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chlorois also utilized in research settings for the exploration of its chemical properties and potential reactions. It can act as a building block for the synthesis of more complex molecules, providing a foundation for the advancement of chemical knowledge and the creation of innovative materials and compounds.

Upstream product

• 351439-07-1 methyl 1H-pyrrolo[2,3-b]pyridine-4-carboxylate 
• 1201748-37-9 4-(methoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine 7-oxide 
• 1190312-37-8 methyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylate 

Relevant articles and documents

N-CYCLOHEXYL-5-(THIAZOL-5-YL)-1H-INDOLE-7-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS CD38 INHIBITORS FOR INCREASING NAD+ AND FOR THE TREATMENT OF E.G. MUSCULAR DISORDERS

The present invention is directed to a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Compounds of Formula (I) are CD38 inhibitors, which can be used to treat a disease or condition in a subject that benefits from an increase in NAD+ or to treat a mitochondrial disorder in a subject. Such disease or condition is a muscle structure disorder, a neuronal activation disorder, a muscle fatigue disorder, a muscle mass disorder, a metabolic disease, a cancer, a vascular disease, an ocular vascular disease, a muscular eye disease, or a renal disease. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 30 to 135; examples 1 to 61; table). Such an exemplary compound is e.g. N-((1r,4r)-4-(2-methoxyethoxy) cyclohexyl)-5-(thiazol-5-yl)-1H-indole-7-carboxamide (II).

NOVEL DERIVATIVES OF PYRROLOINDOLE WHICH ARE INHIBITORS OF HSP90, COMPOSITIONS CONTAINING SAME, AND USE THEREOF

Pyrroloindoles of formula (I) are provided wherein Het is an aromatic or partially unsaturated, monocyclic or bicyclic heterocycle containing between 1 and 4 heteroatoms N, O or S, optionally substituted by R1 or R′1 which are the same or different; R is