1190312-37-8

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, Methyl ester
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, Methyl ester;6-Chloro-7-azaindole-4-carboxylic acid Methyl ester;methyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylate
• CAS NO: 1190312-37-8
• Molecular Formula: C₉H₇ClN₂O₂
• Molecular Weight: 210.61708
• Mol File: 1190312-37-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.453±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.78±0.40(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, Methyl ester(1190312-37-8)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, Methyl ester(1190312-37-8)

Safety Data

• Hazardous Substances Data: 1190312-37-8(Hazardous Substances Data)

Usage

General Description

The chemical "1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, methyl ester" is a methyl ester derivative of 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid with a chlorine substitution at the 6 position. It is a heterocyclic compound with potential pharmaceutical applications. The methyl ester functional group makes it suitable for use in organic synthesis and as a building block for the synthesis of various compounds. Its unique structure and functional groups make it of interest in medicinal chemistry for the development of novel drugs. It may have potential as an active pharmaceutical ingredient in the treatment of various diseases or as a research tool in the study of biological systems.

Upstream product

• 351439-07-1 methyl 1H-pyrrolo[2,3-b]pyridine-4-carboxylate 
• 1201748-37-9 4-(methoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine 7-oxide 
• 479553-01-0 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid 

Downstream Products

• 1261476-04-3 6-phenyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid 
• 1312812-82-0 tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]pyridine-4-carboxamido)methyl)cyclohexyl)methyl]carbamate 
• 1261744-93-7 methyl 6-phenyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylate 
• 1167056-92-9 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid 

Relevant articles and documents

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats

Inhibition of acetyl-CoA carboxylases has the potential for modulating long chain fatty acid biosynthesis and mitochondrial fatty acid oxidation. Hybridization of weak inhibitors of ACC2 provided a novel, moderately potent but lipophilic series. Optimization led to compounds 33 and 37, which exhibit potent inhibition of human ACC2, 10-fold selectivity over inhibition of human ACC1, good physical and in vitro ADME properties and good bioavailability. X-ray crystallography has shown this series binding in the CT-domain of ACC2 and revealed two key hydrogen bonding interactions. Both 33 and 37 lower levels of hepatic malonyl-CoA in vivo in obese Zucker rats.