Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase
The p38 MAP kinase is implicated in the release of the pro-inflammatory cytokines TNFα and IL-1b. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A new lead structure for p38 MAP kinase inhibition was identified. Herein, we report the SAR of this new class of p38 inhibitors.
Laufer, Stefan,Lehmann, Frank
supporting information; body text
p. 1461 - 1464
(2009/11/30)
Novel aromatic compounds and poly(oxyalkylene) containing aromatic compounds possessing antibacterial, antifungal or antitumor activity
The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
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(2008/06/13)
Novel compounds possessing antibacterial, antifungal or antitumor activity
The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
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(2008/06/13)
Synthesis of Novel DNA Binding Agents: Indole-Containing Analogues of Bis-Netropsin
Molecular modelling studies showed that indole dicarboxylic acids are potential linkers for the synthesis of bis-netropsin analogues with a good fit to the minor groove of DNA. To test this hypothesis, 2-carboxyindole-6-acetic acid, indole-2,6-dicarboxyli
Khalaf, Abedawn I.,Pitt, Andrew R.,Suckling, Colin J.,Scobie, Martin,Urwin, John,Waigh, Roger D.,Fishleigh, Robert V.,Young, Stephen C.
p. 751 - 770
(2007/10/03)
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