117140-77-9Relevant academic research and scientific papers
Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase
Laufer, Stefan,Lehmann, Frank
supporting information; body text, p. 1461 - 1464 (2009/11/30)
The p38 MAP kinase is implicated in the release of the pro-inflammatory cytokines TNFα and IL-1b. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A new lead structure for p38 MAP kinase inhibition was identified. Herein, we report the SAR of this new class of p38 inhibitors.
Novel aromatic compounds and poly(oxyalkylene) containing aromatic compounds possessing antibacterial, antifungal or antitumor activity
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, (2008/06/13)
The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
Novel compounds possessing antibacterial, antifungal or antitumor activity
-
, (2008/06/13)
The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
Synthesis of Novel DNA Binding Agents: Indole-Containing Analogues of Bis-Netropsin
Khalaf, Abedawn I.,Pitt, Andrew R.,Suckling, Colin J.,Scobie, Martin,Urwin, John,Waigh, Roger D.,Fishleigh, Robert V.,Young, Stephen C.
, p. 751 - 770 (2007/10/03)
Molecular modelling studies showed that indole dicarboxylic acids are potential linkers for the synthesis of bis-netropsin analogues with a good fit to the minor groove of DNA. To test this hypothesis, 2-carboxyindole-6-acetic acid, indole-2,6-dicarboxyli
