Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors
The discovery and structure-activity relationship of first-generation small-molecule malonyl-CoA decarboxylase (MCD; CoA = coenzyme A) inhibitors are reported. We demonstrated that MCD inhibitors increased malonyl-CoA concentration in the isolated working
Cheng, Jie-Fei,Chen, Mi,Wallace, David,Tith, Souvothy,Haramura, Masayuki,Liu, Bin,Mak, Chi Ching,Arrhenius, Thomas,Reily, Sean,Brown, Steven,Thorn, Vicki,Harmon, Charles,Barr, Rick,Dyck, Jason R. B.,Lopaschuk, Gary D.,Nadzan, Alex M.
Potent CYP19 (aromatase) 1-(benzofuran-2-yl)(phenylmethyl)pyridine, -imidazole, and -triazole inhibitors: Synthesis and biological evaluation
The synthesis of a series of novel 1-[(benzofuran-2-yl)phenylmethyl]- pyridine, -imidazole, and -triazole derivatives is described. All the compounds were evaluated in vitro for inhibitory activity against aromatase (P450 AROM, CYP19), using hu
Saberi, Mohammed Reza,Vinh, Tai Ky,Yee, Sook Wah,Griffiths, B. J. Nathan,Evans, Peter J.,Simons, Claire
p. 1016 - 1022
(2007/10/03)
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