117309-49-6

Basic information

• Product Name: 2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID
• Synonyms: 2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID;2-(4-FLUOROBENZENESULPHAMIDO)-2-PHENYLACETIC ACID;2-(4-FLUOROBENZENESULFAMIDO)-2-PHENYLACETIC ACID;N-(4-FLUOROBENZENESULFONYL)PHENYLGLYCINE;2-(4-FluorophenylsulfonaMido)-2-phenylacetic acid;2-(4-Fluorobenzenesulphamido)-2-phenylaceticacid97%
• CAS NO: 117309-49-6
• Molecular Formula: C₁₄H₁₂FNO₄S
• Molecular Weight: 309.31
• Mol File: 117309-49-6.mol

Chemical Properties

• Melting Point: 179-181°C
• Boiling Point: 490.4°Cat760mmHg
• Flash Point: 250.4°C
• Appearance: /
• Density: 1.426g/cm³
• Vapor Pressure: 1.96E-10mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 2.80±0.10(Predicted)
• CAS DataBase Reference: 2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID(117309-49-6)
• EPA Substance Registry System: 2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID(117309-49-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 117309-49-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID is used as a pharmaceutical intermediate for the development of new drugs. Its unique structure allows for the creation of novel compounds with potential therapeutic properties, making it a valuable asset in drug discovery and design.
Used in Chemical Research:
In the field of chemical research, 2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID serves as a key compound for studying the properties and reactions of sulfonyl compounds and fluorophenyl groups. Its complex structure provides opportunities for exploring new chemical reactions and understanding the behavior of similar compounds.
Used in Material Science:
2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID is used as a building block in the development of new materials with specific properties. Its unique structure can contribute to the creation of materials with tailored characteristics, such as improved stability, reactivity, or selectivity, depending on the application.

InChI:InChI=1/C14H12FNO4S/c15-11-6-8-12(9-7-11)21(19,20)16-13(14(17)18)10-4-2-1-3-5-10/h1-9,13,16H,(H,17,18)/p-1/t13-/m1/s1

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 2935-35-5 (S)-2-phenylglycine 

Relevant articles and documents

N- and 2-Substituted N-(Phenylsulfonyl)glycines as Inhibitors of Rat Lens Aldose Reductase

A variety of N-(phenylsulfonyl)-N-phenylglycines 5, N-(phenylsulfonyl)-2-phenylglycines 6, and N-(phenylsulfonyl)anthranilic acids 7 were prepared as analogues of the N-(phenylsulfonyl)glycine 1 aldose reductase inhibitors.In the rat lens assay, several derivatives of 5 display greater inhibitory activity than the corresponding glycines 1, suggesting that N-phenyl substitution enhances affinity for aldose reductase.Enzyme kinetic evaluations of the 4-benzoylamino analogues of 5 and 1 demonstrate that these compounds produce inhibition by the same mechanism.However, the significant differences in relative inhibitory potencies between compounds of series 5 and 1 may indicate that these compounds do not interact with the inhibitor binding site in precisely the same manner.Evaluation of the individual enantiomers of series 6 reveals that the S isomers are substantially more active than the corresponding R isomers.Also, with the exception of the naphthalene analogue 6n, the S stereoisomers of this series display greater inhibitory potencies than the glycines 1.The anthranilates 7 generally are less active than the glycines 1, demonstrating that direct incorporation of an aromatic ring in the glycine side chain may result in a decrease in affinity for aldose reductase.