349-88-2

Basic information

• Product Name: 4-Fluorobenzenesulfonyl chloride
• Synonyms: 4-fluoro-benzenesulfonylchlorid;P-FLUOROBENZENESULFONYL CHLORIDE;4-FLUOROBENZENSULFONYL CHLORIDE;4-FLUOROBENZENESULPHONYL CHLORIDE;4-FLUOROBENZENESULFONYL CHLORIDE;4-FLUOROBENZENESULFONIC ACID CHLORIDE;4-Fluorobenzenesulfonyl;Benzenesulfonyl chloride, 4-fluoro-
• CAS NO: 349-88-2
• Molecular Formula: C₆H₄ClFO₂S
• Molecular Weight: 194.61
• EINECS: 206-493-0
• Product Categories: Fluorobenzene;Miscellaneous;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;alkyl Fluorine| alkyl chloride
• Mol File: 349-88-2.mol
• Article Data: 40

Chemical Properties

• Melting Point: 29-31 °C(lit.)
• Boiling Point: 95-96 °C2 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: White to light brown/Crystalline Low Melting Mass
• Density: 1.467 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: dioxane: 0.1 g/mL, clear
• Sensitive: Moisture Sensitive
• BRN: 2091633
• CAS DataBase Reference: 4-Fluorobenzenesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluorobenzenesulfonyl chloride(349-88-2)
• EPA Substance Registry System: 4-Fluorobenzenesulfonyl chloride(349-88-2)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-28-36/37/39-45-28A-27
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• TSCA: T
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 349-88-2(Hazardous Substances Data)

Usage

Chemical Properties

white to light brown crystalline low melting mass

InChI:InChI=1/C6H5F.Cl2O2S/c7-6-4-2-1-3-5-6;1-5(2,3)4/h1-5H;

Upstream product

• 462-06-6 fluorobenzene 
• 371-42-6 4-Fluorothiophenol 
• 405-31-2 bis(4-fluorophenyl)disulfide 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 2266-41-3 4-fluorobenzenesulfonylhydrazide 
• 352-34-1 4-fluoro-1-iodobenzene 
• 127-65-1 chloroamine-T 
• 1765-93-1 4-fluoroboronic acid 
• 368-88-7 4-fluorobenzenesulfonic acid 
• 349-89-3 p-chlorobenzenesulfonyl fluoride 
• 371-40-4 4-fluoroaniline 
• 368-85-4 4-fluorobenzenesulfonyl fluoride 

Downstream Products

• 312-32-3 1-[(4-Fluorophenyl)sulfonyl]piperidine 
• 383-23-3 4-[(4-fluorophenyl)sulfonyl]morpholine 
• 339-37-7 4-fluoro-benzenesulfonic acid thiazol-2-ylamide 
• 312-53-8 4-fluoro-N-pyridin-2-yl-benzenesulfonamide 
• 433-01-2 4-fluoro-N-pyrimidin-2-yl-benzenesulfonamide 
• 339-39-9 4-fluoro-benzenesulfonic acid-(5-methyl-[1,3,4]thiadiazol-2-ylamide) 
• 383-29-9 bis(p-fluorophenyl)sulfone 
• 383-28-8 1-bromo-4-((4-fluorophenyl)sulfonyl)benzene 
• 442-65-9 4-fluoro-benzenesulfonic acid-(6-fluoro-[8]quinolylamide) 
• 383-44-8 4-fluoro-benzenesulfonic acid-(4-phenyl-thiazol-2-ylamide) 
• 450-41-9 4-fluoro-benzenesulfonic acid-(4-p-tolyl-thiazol-2-ylamide) 
• 325-00-8 4-fluoro-benzenesulfonic acid-[4-(4-chloro-phenyl)-thiazol-2-ylamide] 
• 575-20-2 4-fluoro-benzenesulfonic acid-[1]naphthylamide 
• 383-39-1 4-fluoro-benzenesulfonic acid-(2,4-dichloro-anilide) 

Relevant articles and documents

Chromoselective Synthesis of Sulfonyl Chlorides and Sulfonamides with Potassium Poly(heptazine imide) Photocatalyst

Among external stimuli used to promote a chemical reaction, photocatalysis possesses a unique one—light. Photons are traceless reagents that provide an exclusive opportunity to alter chemoselectivity of the photocatalytic reaction varying the color of incident light. This strategy may be implemented by using a sensitizer capable to activate a specific reaction pathway depending on the excitation light. Herein, we use potassium poly(heptazine imide) (K-PHI), a type of carbon nitride, to generate selectively three different products from S-arylthioacetates simply varying the excitation light and otherwise identical conditions. Namely, arylchlorides are produced under UV/purple, sulfonyl chlorides with blue/white, and diaryldisulfides at green to red light. A combination of the negatively charged polyanion, highly positive potential of the valence band, presence of intraband states, ability to sensitize singlet oxygen, and multi-electron transfer is shown to enable this chromoselective conversion of thioacetates.

Synthesis, biological evaluation, and enzyme assay of some 5-N-substituted-2-N-(arylsulphonyl)-L(+)glutamines as potential anticancer agents

Thirty 5-N-substituted-2-N-(arylsulphonyl)-L(+)glutamines were synthesized and evaluated biologically for their anticancer activities. The best active compound of this series showed 92.92% inhibition of tumor weight against Ehrlich Ascites Carcinoma cells. The most active compound was proved to be a competitive inhibitor of glutaminase in the enzyme assay. The best active compound may be a starting point to generate 'lead' for further exploration.

Preparation method for symmetric diaryl disulfide

The invention discloses a preparation method for symmetric diaryl disulfide. The preparation method comprises the following steps: using aromatic hydrocarbon as shown in a general formula (I) as a rawmaterial and reacting with chlorosulfonic acid to generate aryl chlorosulfonic acid, and reacting with sulfoxide chloride to synthesize aryl sulfonyl chloride as shown in a general formula (II); andpreparing the symmetric diaryl disulfide as shown in a general formula (III) under the action of a reducing agent through a reduction reaction by the aryl sulfonyl chloride as shown in the general formula (II). The disclosed preparation method for the symmetric diaryl disulfide has many advantages of low toxicity of the reaction raw material, short reaction time, cheap reagents and easy acquisition, convenient separation and purification and the like, and has very high application value and industrial production value.