Synthesis and Radioprotective Activity of Dipeptide Cysteamine and Cystamine Derivatives
Some N-(dipeptidyl)-S-acetylcysteamine and N,N'-(dipeptidyl)cystamine salt derivatives were synthesized and evaluated as canditate radioprotector agents.Toxicity and radioprotective activity as the dose reduction factor (DRF) were determined in vivo on mice and compared to N-glycyl-S-acetylcysteamine trifluoroacetate.One of the most interesting compounds of this series was N-glycylglycyl-S-acetylcysteamine trifluoroacetate (8).
Oiry, Joel,Pue, Jean Y.,Imbach, Jean L.,Fatome, Marc,Sentenac-Roumanou, Henry
p. 297 - 301
(2007/10/02)
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