117500-15-9Relevant articles and documents
Synthesis method of ODMT, N-FMOC-aminobutyl-1, 3-propylene glycol
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Paragraph 0004; 0011-0012, (2021/11/21)
The invention belongs to the technical field of medical intermediates, and concretely relates to a synthesis method of ODMT, N-FMOC-aminobutyl-1, 3-propylene glycol. Diethyl malonate and 4-bromobutyronitrile adopted as starting raw materials are subjected toa substitution reaction, a reduction reaction, an FMOC protection and a DMT protection sequentially to synthesize the ODMT, N-FMOC-aminobutyl-1, 3-propylene glycol. The product synthesized by the synthesis route has characteristics of high purity, high yield and easy operation, and the excellent route is provided for the synthesis of the ODMT, N-FMOC-aminobutyl-1, 3-propylene glycol.
Divergent Gold(I)-Catalyzed Skeletal Rearrangements of 1,7-Enynes
Mei?, Rebecca,Kumar, Kamal,Waldmann, Herbert
supporting information, p. 13526 - 13530 (2015/09/22)
The gold(I) complex catalyzed cycloisomerization and skeletal rearrangement of 1,n-enynes (n=5-7) is a powerful methodology for the efficient synthesis of complex molecular architectures. In contrast to 1,6-enynes, readily accessible homologous 1,7-enynes are largely unexplored in such transformations. Here, the divergent skeletal rearrangement of all-carbon 1,7-enynes by catalysis with a cationic gold(I) complex is reported. Depending on electronic and steric factors, differently substituted 1,7-enynes react via different carbocations formed from a common gold carbene intermediate to yield on the one hand novel exocyclic allenes and on the other hand tricyclic hexahydro-anthracenes through a novel dehydrogenative Diels-Alder reaction. Two birds with a gold-stone! Divergent gold(I) catalysis unraveled a novel cycloisomerization and a dehydrogenative Diels-Alder reaction of 1,7-enynes.
CoCl(PPh3)3 as Cyclotrimerization Catalyst for Functionalized Triynes under Mild Conditions
Jungk, Phillip,Fischer, Fabian,Thiel, Indre,Hapke, Marko
, p. 9781 - 9793 (2015/10/12)
The ubiquitary Co(I) complex CoCl(PPh3)3 was found to be a convenient catalyst for the [2 + 2 + 2] cycloaddition of functionalized triynes under mild reaction conditions and devoid of any additional additive, yielding the substituted
Radical cyclization cascades of unsaturated Meldrum's acid derivatives
Sautier, Brice,Lyons, Sarah E.,Webb, Michael R.,Procter, David J.
supporting information; experimental part, p. 146 - 149 (2012/02/16)
Unsaturated, differentially substituted Meldrum's acid derivatives undergo cascade cyclizations upon ester reduction with SmI2-H2O. The cascade cyclizations proceed in good yield and with high diastereocontrol and convert simple, ach
Tandem cyclization-Michael reaction by combination of metal- and organocatalysis
Aleman, Jose,Del Solar, Virginia,Martin-Santos, Cecilia,Cubo, Leticia,Ranninger, Carmen Navarro
experimental part, p. 7287 - 7293 (2011/10/13)
The use of a catalytic amount of platinum complexes (1 mol%) was found to be compatible with different organocatalysts (DABCO or the Jorgensen- Hayashi catalyst) that were used in the functionalization of various activated methylenes. By this method, a series of lactones with C-3 quaternary centers and substitution at C-5 were prepared.
Targeting the Hsp90 chaperone: Synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90
Day, James E. H.,Sharp, Swee Y.,Rowlands, Martin G.,Aherne, Wynne,Workman, Paul,Moody, Christopher J.
supporting information; experimental part, p. 2758 - 2763 (2010/07/04)
A series of benzo-macrolactones has been prepared by chemical synthesis, and evaluated as inhibitors of heat shock protein 90 (Hsp90), an emerging attractive target for novel cancer therapeutic agents. A new synthesis of these resorcylic acid macrolactone analogues of the natural product radicicol is described in which the key steps are the acylation and ring opening of a homophthalic anhydride to give an isocoumarin, followed by a ring-closing metathesis to form the macrocycle. The methodology has been extended to a novel series of macrolactones incorporating a 1,2,3-triazole ring.
General zinc-catalyzed Conia-ene reactions of 1,3-dicarbonyl compounds with alkynes including the classically challenging substrates under neat conditions
Deng, Chen-Liang,Song, Ren-Jie,Liu, Yi-Lin,Li, Jin-Heng
supporting information; experimental part, p. 3096 - 3100 (2010/04/24)
A simple, versatile new approach to fourmembered ring to six-membered ring products has been developed by zinc-catalyzed intramolecular Conia-ene reactions of 1,3-dicarbonyl compounds with alkynes. This new route allows a wide range of dicarbonyl compounds, including the classically challenging 1,3-diesters and N,N'-disubstituted 1,3-keto amides, to be used for the Conia-ene reaction with inexpensive zinc chloride (ZnCl2) under neat conditions.
