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Diethyl malonate Manufacturer/High quality/Best price/In stock
Cas No: 105-53-3
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TIANFU CHEM 105-53-3 Diethyl malonate
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Diethyl malonate
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diethyl malonate
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USD $ 3.0-3.7 / Kilogram 200 Kilogram 1000 Metric Ton/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Ethyl malonate
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105-53-3 Diethyl malonate
Cas No: 105-53-3
USD $ 40.0-50.0 / Gram 1 Gram 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Diethyl malonate
Cas No: 105-53-3
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier

105-53-3 Usage

Description

As an organic compound, diethyl malonate belongs to the diethyl ester of malonic acid, which is present naturally in guava fruits, melons, grapes, pineapples, blackberries and strawberries as a colorless liquid with an apple-like odor. It is a flavor ingredient commonly found in perfumes, artificial flavorings, alcoholic beverages, various wines and spirits due to its natural pleasant odor. It is also used as an essential intermediate in the syntheses of numerous pharmaceuticals, such as barbiturates, vitamins B1 and B6, non-steroidal anti-inflammatory agents. Besides, diethyl malonate is also involved in organic synthesis of other compounds, such as alpha-aryl malonates, mono-substituted and di-substituted acetic acid. And it can react with benzaldehyde for the production of diethyl benzylidenemalonate in Knoevenagel condensation reaction.

Purification Methods

If too impure (IR, NMR) the ester (250g) is heated on a steam bath for 36hours with absolute EtOH (125mL) and conc H2SO4 (75mL), then fractionally distilled under reduced pressure. Otherwise fractionally distil it under reduced pressure and collect the steady boiling middle fraction. [Beilstein 2 IV 1881.]

Uses

Diethyl Malonate occurs naturally in grapes and strawberries. It is used in the preparation of barbiturates, artificial flavourings, vitamin B1, and vitamin B6 as well as in perfumes.

Uses

manufacture of barbiturates.

Chemical Properties

colourless liquid

References

https://en.wikipedia.org/wiki/Diethyl_malonate
https://pubchem.ncbi.nlm.nih.gov/compound/7761#section=Safety-and-Hazards
https://www.alfa.com/zh-cn/catalog/A15468/
http://www.hmdb.ca/metabolites/HMDB29573
http://www.chemicalland21.com/industrialchem/organic/DIETHYL%20MALONATE.htm
InChI:InChI:1S/C7H12O4/c1-3-10-6(8)5-7(9)11-4-2/h3-5H2,1-2H3

105-53-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A15468)  Diethyl malonate, 99%    105-53-3 10000g 3490.0CNY Detail
Alfa Aesar (A15468)  Diethyl malonate, 99%    105-53-3 2500g 1027.0CNY Detail
Alfa Aesar (A15468)  Diethyl malonate, 99%    105-53-3 500g 335.0CNY Detail

105-53-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Diethyl malonate

1.2 Other means of identification

Product number -
Other names diethyl propanedioate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Fragrances
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:105-53-3 SDS

105-53-3Synthetic route

4-[(3-ethoxy-1,3-dioxopropyl)amino]-benzoic acid
130217-49-1

4-[(3-ethoxy-1,3-dioxopropyl)amino]-benzoic acid

A

N,N'-di-4-carboxyanilide of malonic acid
10256-16-3

N,N'-di-4-carboxyanilide of malonic acid

B

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 5h; Heating;A 98%
B n/a
2-carboxymalonanilic acid ethyl ester
101646-18-8

2-carboxymalonanilic acid ethyl ester

A

N,N'-di-2-carboxyanilide of malonic acid
77317-57-8

N,N'-di-2-carboxyanilide of malonic acid

B

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 5h; Heating;A 98%
B n/a
[di-μ-(ethoxycarbonyl-(methylene))-bis(tricarbonyl-cobalt) (Co-Co)]

[di-μ-(ethoxycarbonyl-(methylene))-bis(tricarbonyl-cobalt) (Co-Co)]

carbon monoxide
201230-82-2

carbon monoxide

A

dicobalt octacarbonyl
61091-28-9, 15226-74-1, 61117-58-6

dicobalt octacarbonyl

B

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
With ethanol In hexane High Pressure; soln. of Co2(CO)8 and EtOH placed in autoclave; pressurized (room temp.,50 bar CO); shaken (60 min); IR; gas chromy.;A 98%
B 95%
4-ethoxymalonanilic acid ethyl ester
4270-39-7

4-ethoxymalonanilic acid ethyl ester

A

N,N'-di-4-ethoxyanilide of malonic acid
4270-37-5

N,N'-di-4-ethoxyanilide of malonic acid

B

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 5h; Heating;A 97%
B n/a
[μ2-(ethoxycarbonyl(methylene))-μ2-(carbonyl)-(tricarbonyl-cobalt)-(triphenylphosphane-dicarbonyl-cobalt) (Co-Co)]

[μ2-(ethoxycarbonyl(methylene))-μ2-(carbonyl)-(tricarbonyl-cobalt)-(triphenylphosphane-dicarbonyl-cobalt) (Co-Co)]

carbon monoxide
201230-82-2

carbon monoxide

A

Co2(CO)7(PPh3)
15906-55-5, 26534-25-8

Co2(CO)7(PPh3)

B

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
With ethanol In dichloromethane High Pressure; soln. of cobalt complex and anhyd. ethanol pressurized with CO in autoclave at 25°C and 50 bar for 24 h; IR;A 97%
B 66%
2-methoxymalonanilic acid ethyl ester
90475-72-2

2-methoxymalonanilic acid ethyl ester

A

N1,N3-bis(2-methoxyphenyl)malonamide
7056-72-6

N1,N3-bis(2-methoxyphenyl)malonamide

B

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 5h; Heating;A 96%
B n/a
2-hydroxy-4-nitromalonanilic acid ethyl ester
43038-58-0

2-hydroxy-4-nitromalonanilic acid ethyl ester

A

N,N'-di-2-hydroxy-4-nitroanilide of malonic acid

N,N'-di-2-hydroxy-4-nitroanilide of malonic acid

B

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 5h; Heating;A 96%
B n/a
Diethyl 2-bromomalonate
685-87-0

Diethyl 2-bromomalonate

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
With bismuth(III) oxide; N-ethyl-N,N-diisopropylamine; para-thiocresol In dichloromethane for 1h; Irradiation;96%
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate In 2,2,2-trifluoroethanol at 20℃; for 4h; UV-irradiation; Sealed tube; Green chemistry;91%
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; N-ethyl-N,N-diisopropylamine; 4,7-bis(thiophen-2-yl)-2,1,3-benzothiadiazole In N,N-dimethyl-formamide for 2.5h; Inert atmosphere; Irradiation;87%
4-carboethoxymalonanilic acid ethyl ester
159657-36-0

4-carboethoxymalonanilic acid ethyl ester

A

N,N'-di-4-carboethoxyanilide of malonic acid
19288-86-9

N,N'-di-4-carboethoxyanilide of malonic acid

B

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 5h; Heating;A 96%
B n/a
[μ2-(ethoxycarbonyl(methylene))-μ2-(carbonyl)-bis(triphenylphosphane-dicarbonyl-cobalt) (Co-Co)]

[μ2-(ethoxycarbonyl(methylene))-μ2-(carbonyl)-bis(triphenylphosphane-dicarbonyl-cobalt) (Co-Co)]

carbon monoxide
201230-82-2

carbon monoxide

A

tricarbonyldi(triphenylphosphine)cobalt(1+) tetracarbonylcobaltate(1-)
14243-08-4

tricarbonyldi(triphenylphosphine)cobalt(1+) tetracarbonylcobaltate(1-)

B

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
With ethanol In dichloromethane High Pressure; soln. of cobalt complex and anhyd. ethanol pressurized with CO in autoclave at 25°C and 50 bar for 24 h; IR;A n/a
B 96%
Diethyl 2-bromomalonate
685-87-0

Diethyl 2-bromomalonate

A

tetraethyl ethane-1,1,2,2-tetracarboxylate
632-56-4

tetraethyl ethane-1,1,2,2-tetracarboxylate

B

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; electrochemical reaction: -1,0 V, 0,1 mol/dm3 Et4NClO4, mercury pool cathode;A 95%
B 5%
With potassium hydrogenphosphate trihydrate; 2,6-di-tert-butyl-4-methyl-phenol In ethanol at 20℃; for 1h; Mechanism; Irradiation; Inert atmosphere; Green chemistry;
Diethyl 2-bromomalonate
685-87-0

Diethyl 2-bromomalonate

EtTe(CH2)3OH
189247-71-0

EtTe(CH2)3OH

A

2-Bromo-2-ethyl-2λ4-[1,2]oxatellurolane

2-Bromo-2-ethyl-2λ4-[1,2]oxatellurolane

B

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
In dichloromethane for 2h; Ambient temperature;A 71%
B 95%
hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

A

diethyl malonate
105-53-3

diethyl malonate

B

CO2

CO2

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 4℃; for 0.5h;A 95%
B n/a
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

diethyl malonate
105-53-3

diethyl malonate

Conditions
ConditionsYield
With sodium ethanolate In ethanol95%

105-53-3Downstream Products

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