Mechanochemical synthesis of aromatic sulfonamides
A three-component Pd-catalysed aminosulfonylation reaction of K2S2O5 and amine with aryl bromides or aromatic carboxylic acids was developed. This strategy was developed to utilise mechanical energy and accommodate primary as well as secondary aliphatic and aromatic amines to provide a new shortcut to a wide range of sulfonamides. Studies on the scope and limitations of the reaction indicated its tolerance of a vast range of functional groups and many structural patterns. The reactions were scaled up to gram quantities.
Mkrtchyan, Satenik,Iaroshenko, Viktor O.
supporting information
p. 11029 - 11032
(2021/11/03)
Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1
The microsomal prostaglandin E2 synthase 1 (mPGES-1) became a desirable target in recent years for the research of new anti-inflammatory drugs. Even though many potent inhibitors of human mPGES-1, tested in vitro assay systems, have been synthe
Synthetic approaches towards the sulfonamide substituted-4,5-diaryl-4H-1,2, 4-triazole-3-thiones
(Chemical Equation Presented) A new series of 3-alkylthio-4,5-diaryl-4H-1, 2,4-triazoles having a SO2NH2 substituent in the para-position on one of the aryl rings (19/25) were prepared starting from the appropriate benzoic acid hydra
Navidpour, Latifeh,Amini, Mohsen,Shafiee, Abbas
p. 1323 - 1331
(2008/09/18)
More Articles about upstream products of 117586-81-9