117666-90-7Relevant articles and documents
Senecio scandens derivative and application thereof in drugs
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, (2018/08/04)
The invention discloses a senecio scandens derivative and application thereof in drugs. The enecio scandens derivative is the derivative of the effective component chlorogenic acid of senecio scandens. The derivative of the chlorogenic acid is a compound as shown in chemical generation formula I, II, III or IV or one or the combination of the stereisomer, geometrical isomer, tautomer, solvate, polymorphic substance, metabolite, ester, pharmaceutically acceptable salt, prodrug, pharmaceutically acceptable prodrug salt, pharmaceutically acceptable carrier, excipient, diluent, adjuvant and intermedium of the compound. The senecio scandens derivative is used for preparing antiviral drugs. The senecio scandens derivative is good in solubility, high in purity, good in antipyretic performance andespecially suitable for being used as the effective component to prepare antipyretic, anti-inflammation and antibacterial drugs.
Compositions for the prevention or treatment of neurodegenerative disease containing alkoxyphenylpropenone derivatives or pharmaceutically acceptable salts thereof as an active ingredient
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Paragraph 0166-0167; 0171-0176; 0350-0351; 0355-0360, (2021/05/28)
PURPOSE: An alkoxyphenylpropenone derivative is provided to efficiently use as a pharmaceutical composition for preventing or treating a degenerative brain disease; or pharmaceutical composition for protecting a brain cell by having an excellent protecting effect of the brain cell. CONSTITUTION: An alkoxyphenylpropenone derivative or a pharmaceutically acceptable salt thereof is indicated as below chemical formula 1; and R^1 is hydrogen or O-R^4; R^2 is hydrogen or O-R^5; R^3 is hydroxy, O-R^6 or -NR^7R^8; R^4, R^5 and R^6 are C_1-C_12 straight chain or a side chain alkyl, C_2-C_12 straight chain or a side chain alkenyl, and unsubstituted or C_5-C_6 aryl which is substituted as C_1-C_4 straight chain, or a side chain alkoxy, C_5-C_6 aryl C_1-C_4 alkyl; R^7 is hydrogen, C_1-C_4 straight chain, or a side chain alkyl; R^8 is hydrogen, the C_1-C_4 straight chain or the side chain alkyl, and the C5-C6 aryl which is unsubstituted or hydroxy-substituted, the C1-C4 alkyl or the C5-C6.