- METHOD FOR THE PREPARATION OF H-ARG (MIS) -OH
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The invention discloses a method for the preparation of N-omega- (1, 2-dimethylindole-3-sulfonyl) -L-arginine and its derivatives using L-ornithine.
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- 1,2-Dimethylindole-3-sulfonyl (MIS) as protecting group for the side chain of arginine
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The protection of arginine (Arg) side chains is a crucial issue in peptide chemistry because of the propensity of the basic guanidinium group to produce side reactions. Currently, sulfonyl-type protecting groups, such as 2,2,5,7,8-pentamethylchroman (Pmc)
- Isidro, Albert,Latassa, Daniel,Giraud, Matthieu,Alvarez, Mercedes,Albericio, Fernando
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experimental part
p. 2565 - 2569
(2009/10/30)
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- INDOLESULFONYL PROTECTING GROUPS FOR PROTECTION OF GUANIDINO AND AMINO GROUPS
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The invention relates to indolesulfonyl halogenides which are useful for the protection of organic compounds comprising at least one guanidino moiety and/or at least one amino group. The invention further relates to a process for their preparation and their use as protecting reagents. The invention also relates to the process for the protecting reaction and to the protected compounds thereof.
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Page/Page column 21-22
(2010/01/29)
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