1177865-17-6 Usage
Uses
Used in Pharmaceutical Research:
NSC 23766 (hydrochloride) is used as a Rac1 inhibitor for investigating the role of Rac1 in diverse cellular functions and its potential as a therapeutic target in various diseases.
Used in Cancer Research:
NSC 23766 (hydrochloride) is used as an inhibitor of the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells, providing insights into the role of Rac1 in cancer progression.
Used in Cell Biology Studies:
NSC 23766 (hydrochloride) is used as a tool compound to study the regulation of cell cycle, cell-cell adhesion, motility, and differentiation by Rac1 activation through its interaction with specific guanine nucleotide exchange factors (GEFs).
Biochem/physiol Actions
NSC23766 is an inhibitor of Rac1, a Rho-family GTPase. The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2.
references
[1]. gao y, dickerson jb, guo f, zheng j, zheng y. rational design and characterization of a rac gtpase-specific small molecule inhibitor. proc natl acad sci u s a. 2004 may 18;101(20):7618-23. [2]. baumer y, spindler v, werthmann rc, bünemann m, waschke j. role of rac 1 and camp in endothelial barrier stabilization and thrombin-induced barrier breakdown. j cell physiol. 2009 sep;220(3):716-26. [3]. jin s1, ray rm, johnson lr. rac1 mediates intestinal epithelial cell apoptosis via jnk. am j physiol gastrointest liver physiol. 2006 dec;291(6):g1137-47.
Check Digit Verification of cas no
The CAS Registry Mumber 1177865-17-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,7,8,6 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1177865-17:
(9*1)+(8*1)+(7*7)+(6*7)+(5*8)+(4*6)+(3*5)+(2*1)+(1*7)=196
196 % 10 = 6
So 1177865-17-6 is a valid CAS Registry Number.
