Chemical Property of NSC 23766 trihydrochloride
Chemical Property:
- PSA：91.99000
- LogP:5.61700
- Storage Temp.:?20°C
- Solubility.:H2O: soluble10mg/mL, clear
- Hydrogen Bond Donor Count:6
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:10
- Exact Mass:529.225427
- Heavy Atom Count:34
- Complexity:514
- Purity/Quality:
-
99%, *data from raw suppliers
Rac1 Inhibitor *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C(N=C3C=C2)C)N)C.Cl.Cl.Cl
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Description
Rac1 is a GTPase that is involved in the regulation of the cell cycle, cell-cell adhesion, motility, and differentiation. Rac1 is activated by its interaction with specific guanine nucleotide exchange factors (GEFs). NSC 23766 is a cell-permeable, reversible inhibitor of Rac1 activation by the Rac-specific GEFs TrioN and Tiam 1 (IC50 = 50 μM). It has no effect on the closely related GTPases, Cdc42 and RhoA. NSC23766 has been used to investigate the role of Rac1 in such diverse cellular functions as stem cell mobilization, epithelial cell migration, angiogenesis, leukemia cell migration and growth, and gene expression.
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Uses
NSC23766 trihydrochloride has been used as a ras-related C3 botulinum toxin substrate 1 (RAC1) inhibitor. NSC 23766 is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.
