117857-93-9Relevant articles and documents
Enantioselective synthesis of L-CCG-I
Chavan, Subhash P.,Sharma, Pallavi,Sivappa, Rasapalli,Bhadbhade, Mohan M.,Gonnade, Rajesh G.,Kalkote, Uttam R.
, p. 6817 - 6819 (2003)
Introduction of natural menthol as the chiral auxiliary in a γ-Br-α,β-unsaturated ester leads to enantioselective generation of three chiral centers in a single step on reaction with a glycine anion equivalent to provide L-CCG-I in 94% ee.
Reactivity of (Bicyclo[5.1.0]octadienyl)iron(1+) Cations: Application to the Synthesis of cis-2-(2′-Carboxycyclopropyl)glycines
Wallock, Nathaniel J.,Donaldson, William A.
, p. 2997 - 3007 (2007/10/03)
The addition of carbon and heteroatom nucleophiles to (bicyclo[5.1.0]octadienyl)Fe(CO)2L+ cations 5 or 8 (L = CO, PPh3) generally proceeds via attack at the dienyl terminus on the face of the ligand opposite to iron to generate 6-substituted (bicyclo[5.1.0]octa-2,4-diene)iron complexes (11 or 13). In certain cases, these products are unstable with respect to elimination of a proton and the nucleophilic substituent to afford (cyclooctatetraene)Fe(CO)2L (4 or 7). Decomplexation of 13f, arising from addition of phthalimide to 8, gave N-(bicyclo[5.1.0]octa-3,5-dien-2-yl)phthalimide (19). Oxidative cleavage of 19 (RuCl3/NaIO4) followed by esterification gave the cyclopropane diester 22, which upon hydrolysis gave cis-2-(2′ -carboxycyclopropyl)glycine (CCG-III, 18) (eight steps from 4, 43% overall yield). This methodology was also utilized for preparation of stereospecifically deuterated CCG-III (d-18) and optically enriched (-)-18. Deprotonation of 22 resulted in cyclopropane ring opening to afford the benzoindolizidine (23).
An efficient and stereoselective synthesis of (2S,1′S,2′S)-2-(carboxycyclopropyl) glycine (LCCG-I): Conformationally constrained L-glutamate analogues
Pajouhesh, Hassan,Chen, John,Pajouhesh, Seyed Hossein
, p. 4537 - 4541 (2007/10/03)
Conformationally restricted metabotropic glutamate receptor agonist (2S,1′S,2′S)-2-(Carboxycyclopropyl) glycine (LCCG-I) 1 have been efficiently synthesized in a stereoselective manner. A convenient five step synthesis of 1 from readily available (-)-dime
Novel enantioselective synthesis of trans-α-(2-carboxycyclo-prop-1- yl)glycines: Conformationally constrained L-glutamate analogues
Demir, Ayhan S.,Tanyeli, Cihangir,Cagir, Ali,Nawaz Tahir,Ulku, Dincer
, p. 1035 - 1042 (2007/10/03)
D- and L-α-(2-carboxycycloprop-1-yl)glycines were synthesized from trans-1,3-di(2-furyl)propenone. Conversion of the double bond to a cyclopropane is followed by the formation of an oxime ether. Enantioselective reduction of the oxime ether, separation of diastereomers and oxidation of the furane rings gave enantiomerically pure D- and L-CCG I and CCG II. The structure of oxime 7b was determined by X-ray crystal structure analysis. The key step is the oxazaborolidine catalyzed enantioselective conversion of oxime ethers to amines.
Facile synthesis of (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine an isotype-selective agonist of metabotropic glutamate receptors
Ma, Dawei,Ma, Zhaochun
, p. 7599 - 7602 (2007/10/03)
(2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine (L-CCG-I) was synthesized in 12 steps and 14% overall yield by using Sharpless's asymmetric dihydroxylation reaction and stereochemically controlled cyclopropanation as key steps.
Study of the reactivity profile of glycine Schiff's bases with dipolarophiles: Application towards a concise synthesis of CCG-II
Chavan, Subhash. P.,Venkatraman,Sharma, Anil. K.,Chittiboyina, Amar Gopal
, p. 2857 - 2858 (2007/10/03)
The reactivity profile of glycine Schiff's bases with crotonate and bromocrotonate has been shown to take a different course depending on the choice substituent on the imine. Application of the above study for the mild and concise synthesis of CCG-II has been achieved.
Synthesis of Four Diastereomeric L-2-(Carboxycyclopropyl)glycines. Conformationally Constrained L-Glutamate Analogues
Shimamoto, Keiko,Ishida, Michiko,Shinozaki, Haruhikio,Ohfune, Yasufumi
, p. 4167 - 4176 (2007/10/02)
To determine what conformations of L-glutamate (L-Glu) activate that compound's different receptors in the mammalian central nervous system, four diastereochemically L-2-(carboxycyclopropyl)glycines, 1-4, which are conformationally constrained analogues o
threo-Selective Michael Addition of N,N-Dibenzylglycinate and Alaninate Enolates to α,β-Unsaturated Esters. A Concise and Stereoselective Synthesis of (+/-)-CCG-II
Yamaguchi, Masahiko,Torisu, Kazuhiko,Minami, Toru
, p. 377 - 380 (2007/10/02)
Lithium enolates of N,N-dibenzylglycinate and alaninate added to β-substituted α,β-unsaturated esters, and threo-adducts were obtained in high stereoselectivities.The reaction was employed in a concise and stereoselective synthesis of (+/-)-CCG-II.
D-3,4-'cyclopropylglutamate' isomers as nmda receptor ligands: Synthesis and enantioselective activity
Pellicciari, Roberto,Natalini, Benedetto,Marinozzi, Maura,Monahan, Joseph B.,Snyder, James P.
, p. 139 - 142 (2007/10/02)
Dirhodium(II) tetraacetate catalyzed decomposition of ethyl diazoacetate in the presence of D-Cbz-vinylglycine methyl ester (11) afforded a mixture of the cyclopropyl esters D-CGA A-D (13) from which the corresponding 2R-acids 7-10 were obtained and their absolute configurations assigned. The (2R,3S,4R) α-(carboxycyclopropyl)glycine (D-CGA C, 9 resulted to be the most potent and selective among the NMDA receptor ligands yet reported.
