- Derivatives of m-Guaiacol, Their Preparation and Their Uses
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The invention concerns derivatives of m-guaiacol, their preparation and their uses as biocides, in particular as antibacterials or disinfectants.
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Paragraph 0125
(2021/11/05)
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- Phenol compound ortho-position direct fluorination method
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The invention relates to a phenol compound ortho-position direct fluorination method which comprises the following steps: reacting a phenol compound shown in a formula (1A) with a fluorination reagentin a solvent under the action of a photocatalyst and a light source at room temperature, and separating and purifying a reaction mixture after the reaction to obtain a fluorinated phenol compound shown in a formula (2A). The advantages are as follows: the method for directly fluorinating phenol by organic photocatalysis is simple in operation process; raw materials are commercialized and easy toobtain; the photocatalyst is low in price, easy to obtain and environmentally friendly; the reaction condition is mild; the site selectivity is high; the reaction is efficient; and a fluorinated phenol derivative can be prepared only through one step.
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Paragraph 0067-0069
(2020/04/17)
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- A practical method for preparation of phenols from arylboronic acids catalyzed by iodopovidone in aqueous medium
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A novel and efficient strategy for the ipso-hydroxylation of arylboronic acids to phenols has been developed using inexpensive, readily available, air-stable water-soluble povidone iodine as catalyst and aqueous hydrogen peroxide as oxidizing agent. The reactions were performed at room temperature under metal-, ligand- and base-free condition in a short reaction time. The corresponding substituted phenols were obtained in moderate to good yields by oxidative hydroxylation of arylboronic acids in aqueous medium.
- Dong, Bin,Ke, Yanxiong,Lu, Guangying,Ren, Jiangmeng,Ren, Yaoyao,Zeng, Bu-Bing,Zhou, Bin
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- Decarboxylative Fluorination of Arylcarboxylic Acids Promoted by ortho-Hydroxy and Amino Groups
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A novel decarboxylative fluorination process has been developed for the synthesis of ortho-hydroxy/amino arylfluorides from salicylic acid analogs, in which the ortho-hydroxy/amino group plays an important role in the transformation. In addition, various arylfluorides are obtained in good to excellent yields under mild conditions.
- Wang, Dinghai,Yuan, Zheliang,Liu, Qilun,Chen, Pinhong,Liu, Guosheng
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p. 507 - 514
(2018/04/25)
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- 3,5-DISUBSTITUTED PYRAZOLES USEFUL AS CHECKPOINT KINASE 1 (CHK1) INHIBITORS, AND THEIR PREPARATIONS AND APPLICATIONS
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Potent inhibitors of Chk1 have the structure formula (I) below. Pharmaceutical compositions comprising the Chk1 inhibitors, uses thereof and their preparation process.
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Paragraph 00091
(2018/02/28)
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- PRODRUG OF TRIAZOLONE COMPOUND
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By oral administration of a compound represented by the following Formula (I): the blood level of Compound (IV): which has an excellent inhibitory action against blood coagulation factor VIIa and the anticoagulant action, reaches a level sufficient for ex
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Page/Page column 97-98
(2011/12/04)
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- 2,3-DIHYDRO-IMINOISOINDOLE DERIVATIVES
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A compound represented by the following general formula (1), or a salt thereof has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. [wherein R1 represents hydrogen, R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc.]
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Page/Page column 29
(2009/10/31)
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- Triazolone derivatives
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A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochem
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Page/Page column 35
(2008/06/13)
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- CHROMAN DERIVATIVES
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3-amino-5-carbamoylchromans and 8-fluoro-3-amino-5-carbamoylchromans, as well as enantiomers and salts thereof, are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are also disclosed. The compounds are useful in the treatment of 5-hydroxytryptamine-mediated disorders of the central nervous system.
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- FACILE PREPARATIONS OF 4-FLUORORESORCINOL
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Two facile methods for preparing 4-fluororesorcinol have been developed.In the first method, the direct fluorination of 1,3-dimethoxybenzene with trifluoromethyl hypofluorite carried out in Freon 11 at -78 deg C afforded 2,4-dimethoxyfluorobenzene.Demethylation by heating under reflux in 48percent HBr in acetic acid gave 4-fluororesorcinol in an overall yield of 60percent.The second method involved the fluorination of 2,6-dimethoxycetophenone by trifluoromethyl hypofluorite in Freon 11 at -78 deg C, leading to 2,6-dimethoxy-3-fluorocetophenone.On heating under reflux in 48percent HBr in acetic acid, 4-fluororesorcinol was obtained in an overall yield of 74percent.The latter is the method of choice for preparing 4-fluororesorcinol.
- Belanger, Patrice C.,Lau, C. K.,Williams, Haydn W. R.,Dufresne, C.,Scheigetz, John
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p. 1479 - 1482
(2007/10/02)
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