Synthesis of some novel benzylidenehydantoins: Amino acids derivatives
5-Benzylidenehydantoin reacts with chlorosulfonic acid to give the corresponding p-sulfonyl chloride. Condensation of the latter with amino acids leads to sulfonylamino acid derivatives, which on coupling with glycine methyl ester hydrochloride in THF-Et
5-(Benzylidene- and o-chlorobenzylidene-) and cinnamylidene-hydantoins reacted with chlorosulfonic acid to give the corresponding p-sulfonyl chlorides (1, 35, 44).These were converted into 49 derivatives by reaction with amines, hydrazines and azide ion.
Cremlyn, Richard,Jethwa, Sanjay,Joiner, Graham,White, David
p. 99 - 110
(2007/10/02)
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