- Synthesis method of chlorthalidone medicine intermediate 2-(3-amino-4-chlorobenzoyl)benzoic acid
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The invention discloses a synthesis method of a chlorthalidone medicine intermediate 2-(3-amino-4-chlorobenzoyl)benzoic acid. The method comprises the following steps: reacting 2-(3-nitro-4-chlorobenzoyl)benzoic acid with cuprous chloride and potassium iodide, washing the obtained reaction product, carrying out suction pumping, and dehydrating the reaction product to obtain 2-(3-amino-4-chlorobenzoyl)benzoic acid. The whole reaction time is controlled to be 8h or shorter, and the reaction yield can reach 90% or above. The method provides a new synthesis route, and lays a good foundation for further increase of the reaction yield.
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Paragraph 0019; 0020; 0021; 0022; 0023
(2016/12/01)
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- Catalytic liquid-phase reduction of aromatic nitro compounds containing highly reactive functional groups
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Improved procedures have been proposed for fast and selective hydrogenation of aromatic nitro compounds with the goal of obtaining practically important amines.
- Zhandarev,Kazin,Mironov
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p. 673 - 676
(2007/10/03)
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- Transfer catalysis between two solids: Application to the reduction of nitroarenes
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A wide range of aromatic nitro compounds can be reduced to anilines through the use of a Cr(II)/Mn0 redox couple in the presence of trimethylsilyl chloride [TMSCl, Eq. (1)]. Only 0.25 equivalents of chromium are required to reduce solid-supported nitroarenes (R = solid support); this represents a rare case of transfer catalysis between two solid phases. The reaction is also amenable to solution-phase synthesis (R = OH).
- Hari, Anitha,Miller, Benjamin L.
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p. 2777 - 2779
(2007/10/03)
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