1181267-36-6

Basic information

• Product Name: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate;Bilastine Impurity 2;4-[1-(2-Ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;N-Boc 1-(2-Ethyoxyethyl)-2-(4-piperidinyl)-1H-benzimidazole;4-[1-(2-Ethoxy-ethyl)-1H-benzoimidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 1181267-36-6
• Molecular Formula: C₂₁H₃₁N₃O₃
• Molecular Weight: 373.48914
• Mol File: 1181267-36-6.mol

Chemical Properties

• Boiling Point: 521.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 5.31±0.10(Predicted)
• CAS DataBase Reference: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate(1181267-36-6)
• EPA Substance Registry System: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate(1181267-36-6)

Safety Data

• Hazardous Substances Data: 1181267-36-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate is used as an impurity in the synthesis of Bilastine (B385000), a novel, nonsedating H1-antihistamine. It is utilized for the symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria due to its effectiveness in alleviating allergy symptoms without causing drowsiness.
As an impurity, it is essential to monitor and control the levels of tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate in the final drug product to ensure safety, efficacy, and quality. The compound may also be of interest for further research into its potential therapeutic applications or as a starting material for the development of new drugs with similar pharmacological properties.

Upstream product

• 628-34-2 2-chloroethyl ethyl ether 
• 953071-73-3 tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 38385-95-4 2-(4-piperidinyl)-1H-benzimidazole 
• 592-55-2 2-Bromoethyl ethyl ether 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 88-74-4 2-nitro-aniline 
• 498-94-2 isonipecotic acid 
• 95-54-5 1,2-diamino-benzene 
• 98139-68-5 2-Ethoxyethyl methanesulphonate 

Downstream Products

• 110963-63-8 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole 
• 1181267-38-8 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester 
• 202189-78-4 Bilastine 

Relevant articles and documents

Preparation method of bilastine important intermediate

According to the preparation method disclosed by the invention, the formula VI is prepared by reacting the formula V with bromoethyl ethyl ether, and a phase transfer catalyst tetrabutylammonium iodide is added, so that the reaction time is greatly shortened. the product of the formula VI is subjected to acid hydrolysis to obtain a compound II. The method is a good method for synthesizing the compound II, is mild in reaction condition, simple to operate and convenient to industrialize, and conforms to the development direction of green chemistry.

Preparation method of bilastine intermediate

The invention belongs to the field of medicinal preparations and specifically relates to a preparation method of a bilastine intermediate named as tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate. An intermediate compound involved in the invention is generated by protecting 2-(4-piperidinyl)-1H-benzimidazole through di-tert butyl dicarbonate and further enabling the 2-(4-piperidinyl)-1H-benzimidazole and 2-chloroethyl ethyl ether to be subjected to a substitution reaction. A product is subjected to deprotection under an acidic condition and then is subjected tothe substitution reaction to generate 1-(2-ethoxy-ethyl)-2-piperidin-4-yl-1H-benzimidazole. The preparation method, provided by the invention, of the bilastine intermediate provides a new way for synthesis of bilastine; used raw materials are cheap and easy to obtain; the preparation cost is low; a whole technology is simple; and the preparation method has relatively high yield and purity and issuitable for industrial large-scale production.

Bilastine preparation method

The invention discloses a Bilastine preparation method. The Bilastine preparation method includes that 2-nitroaniline which is low in price and easy to obtain is taken as a raw material which is subjected to reduction-n-cyclohexylmaleimide reaction, alkyl

Discovery of Novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole Derivatives as Potential Anti-Inflammatory Agents

A novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole derivative 5 with good anti-inflammatory activity was identified from our in-house library. Based on hit compound 5, two series of 2-(piperidin-4-yl)-1H-benzo[d]imidazole derivative 6a-g and 7a-h were designed and synthesized as novel anti-inflammatory agents. Most of synthesized compounds exhibited good inhibitory activity on NO and TNF-α production in LPS-stimulated RAW 264.7 macrophages, in which the compound 6e showed most potent inhibitory activity on NO (IC50 = 0.86 μm) and TNF-α (IC50 = 1.87 μm) production. Further evaluation revealed that compound 6e displayed more potent in vivo anti-inflammatory activity than ibuprofen did on xylene-induced ear oedema in mice. Additionally, Western blot analysis revealed that compound 6e could restore phosphorylation level of IκBα and protein expression of p65 NF-κB in LPS-stimulated RAW 264.7 macrophages.

NOVEL PROCESS FOR THE PREPARATION OF 2-[4-(2-{4-[1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL]-1-PIPERIDINYL}ETHYL) PHENYL]-2-METHYLPROPANOIC ACID

The present invention relates to novel process for the preparation of 2-[4-(2-{4-[l-(2- ethoxyethyl)-lH-benzimidazol-2-yl]-l-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid represented by the following structural formula- 1. Formula- 1 The present invention also provides novel intermediate compounds useful for the preparation of compound of formula- 1.

PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS

The present invention relates to a process for preparing 2-methyl-2′-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present inv

Alternative synthesis of bilastine

A new and efficient synthesis of the non-sedating histamine H1 receptor antagonist Bilastine is reported. The new route employs a convergent strategy, with a longest linear sequence of five steps, giving slightly improved yields over the previous routes.

PROCESS FOR PREPARATION OF 2-METHYL-2′-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS

The present invention relates to a process for preparing 2-methyl-2'-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present inv