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CAS

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118288-67-8

2-(4-chlorophenyl)-5,6-dihydro[1]benzothiepino[5,4-c]pyridazin-3(2H)-one 7-oxide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 118288-67-8 Structure

  • Basic information

    1. Product Name: 2-(4-chlorophenyl)-5,6-dihydro[1]benzothiepino[5,4-c]pyridazin-3(2H)-one 7-oxide
    2. Synonyms: (1)Benzothiepino(5,4-c)pyridazin-3(2H)-one, 2-(4-chlorophenyl)-5,6-dihydro-, 7-oxide
    3. CAS NO:118288-67-8
    4. Molecular Formula: C18H13ClN2O2S
    5. Molecular Weight: 356.826
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 118288-67-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 603.6°C at 760 mmHg
    3. Flash Point: 318.8°C
    4. Appearance: N/A
    5. Density: 1.48g/cm3
    6. Vapor Pressure: 1.6E-14mmHg at 25°C
    7. Refractive Index: 1.739
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-(4-chlorophenyl)-5,6-dihydro[1]benzothiepino[5,4-c]pyridazin-3(2H)-one 7-oxide(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-(4-chlorophenyl)-5,6-dihydro[1]benzothiepino[5,4-c]pyridazin-3(2H)-one 7-oxide(118288-67-8)
    12. EPA Substance Registry System: 2-(4-chlorophenyl)-5,6-dihydro[1]benzothiepino[5,4-c]pyridazin-3(2H)-one 7-oxide(118288-67-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 118288-67-8(Hazardous Substances Data)

118288-67-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 118288-67-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,2,8 and 8 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 118288-67:
(8*1)+(7*1)+(6*8)+(5*2)+(4*8)+(3*8)+(2*6)+(1*7)=148
148 % 10 = 8
So 118288-67-8 is a valid CAS Registry Number.

118288-67-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-chlorophenyl)-7-oxo-5,6-dihydro-[1]benzothiepino[5,4-c]pyridazin-3-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:118288-67-8 SDS

118288-67-8Downstream Products

118288-67-8Relevant articles and documents

Pharmaceutical composition with improved dissolution property

-

, (2008/06/13)

Pharmaceutical compositions with improved dissolution property, which are obtained by mixing and pulverizing benzothiepino[5,4-c]pyridazine compounds represented by the formula with starch(es) derived from various plants and/or derivative(s) thereof at a weight ratio of 1:4 - 2:1, preferably 1:2 - 2:1, followed by addition of additives normally used for pharmaceutical preparations and formulation thereof into preparations are disclosed. The pharmaceutical compositions of the invention exhibit superior dissolution-improving effect accompanied by enhancement of the solubility of the Compound (I) per se as compared with that when the Compound alone is dissolved.

Studies on the synthesis of condensed pyridazine derivatives. IV. Synthesis and anxiolytic activity of 2-aryl-5,6-dihydro-(1)benzothiepino[5,4-c]pyridazin-3(2H)-ones and related compound

Nakao,Obata,Kawakami,Morita,Tanaka,Morimoto,Takehara,Yakushiji,Tahara

, p. 2556 - 2563 (2007/10/02)

A series of 2-aryl-5,6-dihydro-(1)benzothiepino[5,4-c]pyridazin-3(2H)-ones and related compounds were synthesized and evaluated for their ability to displace 3H-diazepam from rat brain membranes in vitro, and to prevent bicuculline induced convulsions in mice in vivo. Compounds with a 4'-methoxyphenyl (36) or 4'-chlorophenyl group (37, 39-42) as 2-aryl substituents showed prominent activities in both the in vitro and in vivo tests. Among them, 2-(4'-chlorophenyl)-5,6-dihydro- (37) and 2-(4'-chlorophenyl)-5,6-dihydro-10-fluoro-(1)benzothiepino[5,4-c]pyrida zin-3(2H)-one 7-oxides (41) showed activity twice as potent as diazepam in an anticonflict test (Vogel type, rats) while exhibiting less muscle relaxation (rotarod test, mice) and augmentation of γ-aminobutyric acid-induced chloride current (I(cl)) in isolated frog sensory neurones than diazepam. Compound 37 (Y-23684) was selected from this series as a candidate for further development. The structure-activity relationships are discussed.

Anti-anxiety benzothiepino(5,4-c]pyridazines

-

, (2008/06/13)

A benzothiepino 5,4-c]pyridazine compound of the formula: STR1 wherein R 1 and R 2 are the same or different and each is hydrogen, halogen, trifluoromethyl, hydroxy, amino, nitro, cyano, C 1-4 alkyl, C 1-4 alkoxy, or C 2-5 alkanoylamino, R 3 is hydrogen,

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