118420-00-1

Basic information

• Product Name: 2-PROPENOIC ACID, 3-(6-CHLORO-3-PYRIDINYL)-, (E)-
• Synonyms: 2-PROPENOIC ACID, 3-(6-CHLORO-3-PYRIDINYL)-, (E)-;(E)-3-(6-Chloropyridin-3-yl)acrylic acid;3-(6-Chloropyridin-3-yl)-acrylic acid
• CAS NO: 118420-00-1
• Molecular Formula: C₈H₆ClNO₂
• Molecular Weight: 183.59174
• Mol File: 118420-00-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-PROPENOIC ACID, 3-(6-CHLORO-3-PYRIDINYL)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PROPENOIC ACID, 3-(6-CHLORO-3-PYRIDINYL)-, (E)-(118420-00-1)
• EPA Substance Registry System: 2-PROPENOIC ACID, 3-(6-CHLORO-3-PYRIDINYL)-, (E)-(118420-00-1)

Safety Data

• Hazardous Substances Data: 118420-00-1(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
2-Propenoic Acid, 3-(6-Chloro-3-Pyridinyl)-, (E)is used as a key intermediate in the synthesis of various chemical products. Its unique structure and reactivity make it a valuable component in the production of a wide range of compounds, including pharmaceuticals, agrochemicals, and specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Propenoic Acid, 3-(6-Chloro-3-Pyridinyl)-, (E)is used as a building block for the development of new drugs. Its specific molecular structure allows for the creation of novel compounds with potential therapeutic applications, such as antibiotics, anti-inflammatory agents, and antiviral medications.
Used in Agrochemical Industry:
2-Propenoic Acid, 3-(6-Chloro-3-Pyridinyl)-, (E)is employed as a starting material in the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties enable the production of effective and targeted compounds that can protect crops from pests and diseases, thereby increasing agricultural productivity.
Used in Specialty Chemicals:
In the specialty chemicals sector, 2-Propenoic Acid, 3-(6-Chloro-3-Pyridinyl)-, (E)is utilized in the production of various high-value compounds, such as dyes, pigments, and coatings. Its unique properties contribute to the development of innovative products with enhanced performance characteristics, such as improved color stability and resistance to environmental factors.

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 23100-12-1 6-chloronicotinylaldehyde 
• 141-82-2 malonic acid 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 

Downstream Products

• 118420-40-9 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(6-chloro-pyridin-3-yl)-acrylamide 
• 188916-07-6 (S)-2-amino-3-(6-chloropyridin-3-yl)propanoic acid 

Relevant articles and documents

Synthesis of Enantiomerically Pure Ring-Substituted l -Pyridylalanines by Biocatalytic Hydroamination

Current routes to nitrogen-containing heteroarylalanines involve complex multistep synthesis and are often reliant on protection/deprotection steps and wasteful chromatographic purifications. In order to complement existing methodologies, a convenient telescopic strategy was developed for the synthesis of l-pyridylalanine analogues (12 examples) and other l-heteroarylalanines (5 examples) starting from the corresponding aldehydes. A phenylalanine ammonia lyase (PAL) from Anabaena variabilis was used as the biocatalyst to give conversions ranging between 88 and 95%, isolated yields of 32-60%, and perfect enantiopurity (>99% ee) by employing an additional deracemization cascade where necessary.

Tetrazole amide derivatives of heterocyclic alkenyl acid and their use as antiallergic substances

Tetrazole amide derivatives of heterocyclic alkenyl acids, of general formula STR1 in which Y=NH, O or S when m=1; Y=N when m=2; m=1 or 2; l=0 or 4; R=H, C1-4 alkyl, Cl, Br, CF3, CH2 OCOCH3, or OCH2 -Ph; R1 =H, alkaline metal or alkaline earth metal, the double bond of the alkenyl chain being of trans or cis configuration and the possible benzene ring being unsubstituted or substituted. Such derivatives possess high antiallergic activity.

Tetrazole amide derivatives of heterocyclic alkenyl acids and their use as antiallergic substances

Tetrazole amide derivatives of heterocyclic alkenyl acids, of general formula (I): in which, Y = NH, O or S when m = 1;, Y = N when m = 2;, m = 1 or 2;, l = 0 or 4;, R = H, C1 4 alkyl, Cl, Br, CF3, CH2OCOCH3, or OCH2-Ph;, R1 = H, alkaline metal or alkaline earth metal;, the double bond of the alkenyl chain being of trans or cis configuration and the possible benzene ring being unsubstituted or substituted. Said derivatives possess high antiallergic activity.

Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides

A new series of 3-(3-pyridyl)acrylamides 16, 17, 19, and 26, and 5-(3-pyridyl)-2,4-pentadienamides 20-25 were prepared and evaluated for their antiallergic activity. Several of these compounds exhibited more potent inhibitory activities than the parent compounds 1a [(E)-N-[4 [4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamide] against the rat passive cutaneous anaphylaxis (PCA) reaction and the enzyme 5-lipoxygenase. Particularly, 4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3-pyridyl)acrylamide (17p) showed an ED50 value of 3.3 mg/kg po in the rat PCA test, which was one-fifth of ketotifen and oxatomide. As compared with ketotifen and oxatomide, compound 17p (AL-3264) possessed a better balance of antiallergic properties due to inhibition of chemical mediator release, inhibition of 5-lipoxygenase, and antagonism of histamine.