- The use of mixtures of ligands in the Ir-catalyzed asymmetric reductive amination of 6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one
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A comparative testing of complex catalysts with homo and hetero combinations of chiral and achiral monodentate phosphite- and phosphine-type ligands in the Ir-catalyzed asymmet- ric direct reductive amination of 2,3,4,9-tetrahydro-1H-carbozol-1-ones was carried out. A positive effect of the use in the reaction of a mixture of chiral and achiral ligands was demonstrated. This approach makes feasible a one-pot synthesis of valuable biologically active compounds of (tetrahydro-1H-carbazol-1-yl)amine series.
- Lyubimov,Ozolin,Pavlov,Ivanov, P. Yu,Mayorov,Velezheva,Davankov,Nikonenko
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- Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents
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Several 6-substituted tetrahydrocarbazole derivatives were designed, synthesized and evaluated for the antibacterial activities against Staphylococcus aureus Newman strain. Subsequently, 2,4-diaminopyrimidine scaffold was merged with the tetrahydrocarbazole unit to generate a series of novel hybrid derivatives and the antibacterial activities were also investigated. Among these novel hybrids, compound 12c showed the most potent activity with a MIC of 0.39–0.78 μg/mL against S. aureus Newman and Escherichia coli AB1157 strain. In addition, compound 12c exhibited low MIC values against a panel of multidrug-resistant strains of S. aureus.
- Su, Liqiang,Li, Jiahui,Zhou, Zhen,Huang, Dongxia,Zhang, Yuanjin,Pei, Haixiang,Guo, Weikai,Wu, Haigang,Wang, Xin,Liu, Mingyao,Yang, Cai-Guang,Chen, Yihua
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p. 203 - 211
(2018/11/23)
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- COMPOSITIONS AND METHODS FOR VIRAL INHIBITION
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The present invention discloses methods and compositions for viral inhibition, particularly inhibition of HCV and SARS. The invention also provides compositions including carbazole derivatives useful for viral inhibition.
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Page/Page column 37
(2010/02/11)
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- SYNTHESIS OF HETEROCYCLES ON THE BASIS OF IMINOTETRAHYDROCARBAZOLES. 1. 3-BENZYL-8-METHYL-2-OXO-2,3,3a,4,5,6-HEXAHYDRO-1H-PYRAZINOCARBAZOLE
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The reaction of 6-methyl-1-oxo-1,2,3,4-tetrahydrocarbazole and benzylamine gave 1-benzylimino-6-methyl-1,2,3,4-tetrahydrocarbazole, which was converted by two methods to a pyrazinocarbazole derivative.The promising character of the use of iminotetrahydroc
- Bokanov, A. I.,Ivanov, P. Yu.,Akalaeva, T. V.,Bogdanova, G. A.,Shvedov, V. I.
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p. 1311 - 1315
(2007/10/02)
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