118498-98-9

Basic information

• Product Name: AURORA KA-7529
• Synonyms: CHEMBRDG-BB 5869604;AURORA KA-7529;N-BENZYL-6-METHYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-AMINE;N-benzyl-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine(SALTDATA: HCl)
• CAS NO: 118498-98-9
• Molecular Formula: C₂₀H₂₂N₂
• Molecular Weight: 290.4
• Mol File: 118498-98-9.mol

Chemical Properties

• Boiling Point: 486.8°C at 760 mmHg
• Flash Point: 248.2°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 1.26E-09mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: AURORA KA-7529(CAS DataBase Reference)
• NIST Chemistry Reference: AURORA KA-7529(118498-98-9)
• EPA Substance Registry System: AURORA KA-7529(118498-98-9)

Safety Data

• Hazardous Substances Data: 118498-98-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H22N2/c1-14-10-11-18-17(12-14)16-8-5-9-19(20(16)22-18)21-13-15-6-3-2-4-7-15/h2-4,6-7,10-12,19,21-22H,5,8-9,13H2,1H3

Upstream product

• 115174-30-6 1-benzylimino-6-methyl-1,2,3,4-tetrahydrocarbazole 
• 3449-48-7 6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one 
• 100-46-9 benzylamine 
• 637-60-5 p-tolylhydrazine hydrochloride 
• 765-87-7 cyclohexane-1,2-dione 

Downstream Products

• 115174-37-3 N-benzyl-N-(6-methyl-1,2,3,4-tetrahydro-1-carbazolyl)acetamide 
• 115174-31-7 3-benzyl-6-methyl-2-oxo-2,3,3a,4,5,6-hexahydro-1H-pyrazine<3,2,1-j,k>carbazole 
• 115174-35-1 N-benzyl-N-(6-methyl-1,2,3,4-tetrahydro-1-carbazolyl)chloroacetamide 

Relevant articles and documents

The use of mixtures of ligands in the Ir-catalyzed asymmetric reductive amination of 6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one

A comparative testing of complex catalysts with homo and hetero combinations of chiral and achiral monodentate phosphite- and phosphine-type ligands in the Ir-catalyzed asymmet- ric direct reductive amination of 2,3,4,9-tetrahydro-1H-carbozol-1-ones was carried out. A positive effect of the use in the reaction of a mixture of chiral and achiral ligands was demonstrated. This approach makes feasible a one-pot synthesis of valuable biologically active compounds of (tetrahydro-1H-carbazol-1-yl)amine series.

Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents

Several 6-substituted tetrahydrocarbazole derivatives were designed, synthesized and evaluated for the antibacterial activities against Staphylococcus aureus Newman strain. Subsequently, 2,4-diaminopyrimidine scaffold was merged with the tetrahydrocarbazole unit to generate a series of novel hybrid derivatives and the antibacterial activities were also investigated. Among these novel hybrids, compound 12c showed the most potent activity with a MIC of 0.39–0.78 μg/mL against S. aureus Newman and Escherichia coli AB1157 strain. In addition, compound 12c exhibited low MIC values against a panel of multidrug-resistant strains of S. aureus.

COMPOSITIONS AND METHODS FOR VIRAL INHIBITION

The present invention discloses methods and compositions for viral inhibition, particularly inhibition of HCV and SARS. The invention also provides compositions including carbazole derivatives useful for viral inhibition.

SYNTHESIS OF HETEROCYCLES ON THE BASIS OF IMINOTETRAHYDROCARBAZOLES. 1. 3-BENZYL-8-METHYL-2-OXO-2,3,3a,4,5,6-HEXAHYDRO-1H-PYRAZINOCARBAZOLE

The reaction of 6-methyl-1-oxo-1,2,3,4-tetrahydrocarbazole and benzylamine gave 1-benzylimino-6-methyl-1,2,3,4-tetrahydrocarbazole, which was converted by two methods to a pyrazinocarbazole derivative.The promising character of the use of iminotetrahydroc