cas 118515-48-3, 4-methoxy-8-(ribofuranosylamino)pyrimido(5,4-d)pyrimidine | Articles data ｜lookchem

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118515-48-3

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Substituted pyrimido[5,4-d]pyrimidine nucleosides
α and β-ribonucleosides of substituted pyrimido[5,4-d]pyrimidines are used in treating malignant tumors in vivo. A novel synthesis for preparing these compounds and other related compounds is further disclosed.
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(2008/06/13)

Antitumor and antiviral activity of synthetic α- and β-ribonucleosides of certain substituted pyrimido[5,4-d]pyrimidines: a new synthetic strategy for exocyclic aminonucleosides
A novel and direct synthesis of the antiviral and antitumor agent 4-amino-8-(β-D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine (ARPP, 8) and its α-anomer (11) has been developed. Treatment of 2,4,6,8-tetrachloro-pyrimido[5,4-d]pyrimidine (1) with 2,3-O-iso
Sanghvi,Larson,Matsumoto,Nord,Smee,Willis,Avery,Robins,Revankar
p. 629 - 637
(2007/10/02)

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Chemical Properties

Boiling Point: 639.5°Cat760mmHg
Flash Point:340.6°C
Density: 1.642g/cm³
Vapor Pressure: 3.14E-17mmHg at 25°C
PSA: 142.74000
LogP: -1.64770

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