Synthesis of Diastereoenriched α-Aminomethyl Enaminones via a Br?nsted Acid-Catalyzed Asymmetric aza-Baylis-Hillman Reaction of Chiral N-Phosphonyl Imines
An effective chiral GAP methodology for preparing α-aminomethyl enaminones through a (R)-CSA-catalyzed asymmetric aza-Baylis-Hillman reaction is reported. Excellent yields and high diastereoselectivity could be obtained under mild conditions and convenient GAP techniques. The confirmations of the absolute configuration of N-phosphonyl imine and chiral enaminone by X-ray diffraction provides an explicit explanation of the chirality mechanism for GAP chemistry.
Liu, Yangxue,Ahmed, Sultan,Qin, Xiao-Yan,Rouh, Hossein,Wu, Guanzhao,Li, Guigen,Jiang, Bo
p. 1125 - 1131
(2020/03/19)
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